Impact of nonhybrid 99mTc-MDP-SPECT/CT image fusion in diagnostic and treatment of oromaxillofacial malignancies

Denys John Loeffelbein; Eckhart Mielke; Andreas Konrad Buck; Marco Rainer Kesting; Frank Hölzle; Thomas Mücke; Steffen Müller; Klaus Dietrich Wolff

doi:10.1007/s11307-009-0231-2

Impact of nonhybrid ^99mTc-MDP-SPECT/CT image fusion in diagnostic and treatment of oromaxillofacial malignancies

Denys John Loeffelbein
, Eckhart Mielke
, Andreas Konrad Buck
, Marco Rainer Kesting
, Frank Hölzle
, Thomas Mücke
, Steffen Müller
, Klaus Dietrich Wolff

Chair of Odontology, in particular Oral and Maxillofacial Surgery

Technical University of Munich
Max-Planck-lnstitut für Kohlenforschung

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Purpose: The aim of this study was to prospectively investigate the clinical impact of image fusion of computed tomography (CT) and single photon emission computed tomography (SPECT) diagnostics in head and neck cancer adjacent or fixed to bony maxillofacial structures. Procedures: Computer-based manual image fusion has been applied in 74 patients with suspected malignancies in the oromaxillofacial region following CT and SPECT. Afterward, image fusion was compared to separate evaluation of CT and SPECT and visual coregistration with histopathological results serving as control. Results: In nine out of 74 patients, image fusion achieved more precise anatomical findings regarding tumor dimension than simultaneous evaluation of CT and SPECT, but there was no improvement of identification of bone infiltration. Conclusion: Manual image fusion of CT and SPECT does not improve identification of bone infiltration compared to simultaneous evaluation. Though particularly in complex anatomical regions, a fixed preoperative diagnostic algorithm in image registration lead to a more precise evaluation and treatment of head and neck malignancies.

Original language	English
Pages (from-to)	71-77
Number of pages	7
Journal	Molecular Imaging and Biology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/s11307-009-0231-2
State	Published - Feb 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bone infiltration
CT
Image fusion
Maxillofacial malignancies
Tc-MDP-SPECT

Access to Document

10.1007/s11307-009-0231-2

Cite this

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title = "Impact of nonhybrid 99mTc-MDP-SPECT/CT image fusion in diagnostic and treatment of oromaxillofacial malignancies",

abstract = "Purpose: The aim of this study was to prospectively investigate the clinical impact of image fusion of computed tomography (CT) and single photon emission computed tomography (SPECT) diagnostics in head and neck cancer adjacent or fixed to bony maxillofacial structures. Procedures: Computer-based manual image fusion has been applied in 74 patients with suspected malignancies in the oromaxillofacial region following CT and SPECT. Afterward, image fusion was compared to separate evaluation of CT and SPECT and visual coregistration with histopathological results serving as control. Results: In nine out of 74 patients, image fusion achieved more precise anatomical findings regarding tumor dimension than simultaneous evaluation of CT and SPECT, but there was no improvement of identification of bone infiltration. Conclusion: Manual image fusion of CT and SPECT does not improve identification of bone infiltration compared to simultaneous evaluation. Though particularly in complex anatomical regions, a fixed preoperative diagnostic algorithm in image registration lead to a more precise evaluation and treatment of head and neck malignancies.",

keywords = "Bone infiltration, CT, Image fusion, Maxillofacial malignancies, Tc-MDP-SPECT",

author = "Loeffelbein, \{Denys John\} and Eckhart Mielke and Buck, \{Andreas Konrad\} and Kesting, \{Marco Rainer\} and Frank H{\"o}lzle and Thomas M{\"u}cke and Steffen M{\"u}ller and Wolff, \{Klaus Dietrich\}",

year = "2010",

month = feb,

doi = "10.1007/s11307-009-0231-2",

language = "English",

volume = "12",

pages = "71--77",

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TY - JOUR

T1 - Impact of nonhybrid 99mTc-MDP-SPECT/CT image fusion in diagnostic and treatment of oromaxillofacial malignancies

AU - Loeffelbein, Denys John

AU - Mielke, Eckhart

AU - Buck, Andreas Konrad

AU - Kesting, Marco Rainer

AU - Hölzle, Frank

AU - Mücke, Thomas

AU - Müller, Steffen

AU - Wolff, Klaus Dietrich

PY - 2010/2

Y1 - 2010/2

N2 - Purpose: The aim of this study was to prospectively investigate the clinical impact of image fusion of computed tomography (CT) and single photon emission computed tomography (SPECT) diagnostics in head and neck cancer adjacent or fixed to bony maxillofacial structures. Procedures: Computer-based manual image fusion has been applied in 74 patients with suspected malignancies in the oromaxillofacial region following CT and SPECT. Afterward, image fusion was compared to separate evaluation of CT and SPECT and visual coregistration with histopathological results serving as control. Results: In nine out of 74 patients, image fusion achieved more precise anatomical findings regarding tumor dimension than simultaneous evaluation of CT and SPECT, but there was no improvement of identification of bone infiltration. Conclusion: Manual image fusion of CT and SPECT does not improve identification of bone infiltration compared to simultaneous evaluation. Though particularly in complex anatomical regions, a fixed preoperative diagnostic algorithm in image registration lead to a more precise evaluation and treatment of head and neck malignancies.

AB - Purpose: The aim of this study was to prospectively investigate the clinical impact of image fusion of computed tomography (CT) and single photon emission computed tomography (SPECT) diagnostics in head and neck cancer adjacent or fixed to bony maxillofacial structures. Procedures: Computer-based manual image fusion has been applied in 74 patients with suspected malignancies in the oromaxillofacial region following CT and SPECT. Afterward, image fusion was compared to separate evaluation of CT and SPECT and visual coregistration with histopathological results serving as control. Results: In nine out of 74 patients, image fusion achieved more precise anatomical findings regarding tumor dimension than simultaneous evaluation of CT and SPECT, but there was no improvement of identification of bone infiltration. Conclusion: Manual image fusion of CT and SPECT does not improve identification of bone infiltration compared to simultaneous evaluation. Though particularly in complex anatomical regions, a fixed preoperative diagnostic algorithm in image registration lead to a more precise evaluation and treatment of head and neck malignancies.

KW - Bone infiltration

KW - CT

KW - Image fusion

KW - Maxillofacial malignancies

KW - Tc-MDP-SPECT

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