Impact of expression of the uPA system in sarcomas

Helge Taubert; Viktor Magdolen; Matthias Kotzsch

doi:10.2217/bmm.12.105

Impact of expression of the uPA system in sarcomas

Helge Taubert
, Viktor Magdolen
, Matthias Kotzsch

Department of Gynecology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 and uPA receptor and their relevance to clinical and survival data in sarcomas underlining their impact as tumor biomarkers in this tumor type as well.

Original language	English
Pages (from-to)	473-480
Number of pages	8
Journal	Biomarkers in Medicine
Volume	7
Issue number	3
DOIs	https://doi.org/10.2217/bmm.12.105
State	Published - Jun 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

PAI-1
soft tissue and bone sarcoma
uPA
uPA receptor

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10.2217/bmm.12.105

Cite this

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abstract = "The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 and uPA receptor and their relevance to clinical and survival data in sarcomas underlining their impact as tumor biomarkers in this tumor type as well.",

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AB - The uPA system mainly comprises the urokinase-type plasminogen activator uPA, the cell-surface receptor uPA receptor and the inhibitor PAI-1. Its clinical and prognostic impact especially in breast cancer is well investigated. In this short report, we summarize the published data describing expression of uPA, PAI-1 and uPA receptor and their relevance to clinical and survival data in sarcomas underlining their impact as tumor biomarkers in this tumor type as well.

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KW - soft tissue and bone sarcoma

KW - uPA

KW - uPA receptor

UR - https://www.scopus.com/pages/publications/84878741029

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M3 - Article

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Impact of expression of the uPA system in sarcomas

Abstract

UN SDGs

Keywords

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