Abstract
Currently two calcineurin inhibitors (cyclosporin A, tacrolimus), three DNA synthesis inhibitors (mycophenolate, mycophenolatmofetil, azathioprin) and two TOR inhibitors (everolimus, sirolimus) are used for immunosuppressant therapy in kidney transplant recipients. Steroids and different types of antibodies may extend immunosuppressant regimens. The present article discusses pharmacokinetic data, adverse effects and interaction profiles of these drugs and the possibilities opened up by various combinations in current use and their limitations; it also deals with current guidelines on treating rejection.
| Translated title of the contribution | Immunosuppressants in the treatment of kidney transplant recipients |
|---|---|
| Original language | German |
| Pages (from-to) | 157-166 |
| Number of pages | 10 |
| Journal | Nephrologe |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2007 |
| Externally published | Yes |