TY - JOUR
T1 - Immunology of COVID-19
T2 - Mechanisms, clinical outcome, diagnostics, and perspectives—A report of the European Academy of Allergy and Clinical Immunology (EAACI)
AU - Sokolowska, Milena
AU - Lukasik, Zuzanna M.
AU - Agache, Ioana
AU - Akdis, Cezmi A.
AU - Akdis, Deniz
AU - Akdis, Mübeccel
AU - Barcik, Weronika
AU - Brough, Helen A.
AU - Eiwegger, Thomas
AU - Eljaszewicz, Andrzej
AU - Eyerich, Stefanie
AU - Feleszko, Wojciech
AU - Gomez-Casado, Cristina
AU - Hoffmann-Sommergruber, Karin
AU - Janda, Jozef
AU - Jiménez-Saiz, Rodrigo
AU - Jutel, Marek
AU - Knol, Edward F.
AU - Kortekaas Krohn, Inge
AU - Kothari, Akash
AU - Makowska, Joanna
AU - Moniuszko, Marcin
AU - Morita, Hideaki
AU - O'Mahony, Liam
AU - Nadeau, Kari
AU - Ozdemir, Cevdet
AU - Pali-Schöll, Isabella
AU - Palomares, Oscar
AU - Papaleo, Francesco
AU - Prunicki, Mary
AU - Schmidt-Weber, Carsten B.
AU - Sediva, Anna
AU - Schwarze, Jürgen
AU - Shamji, Mohamed H.
AU - Tramper-Stranders, Gerdien A.
AU - van de Veen, Willem
AU - Untersmayr, Eva
N1 - Publisher Copyright:
© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - With the worldwide spread of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) resulting in declaration of a pandemic by the World Health Organization (WHO) on March 11, 2020, the SARS-CoV-2-induced coronavirus disease-19 (COVID-19) has become one of the main challenges of our times. The high infection rate and the severe disease course led to major safety and social restriction measures worldwide. There is an urgent need of unbiased expert knowledge guiding the development of efficient treatment and prevention strategies. This report summarizes current immunological data on mechanisms associated with the SARS-CoV-2 infection and COVID-19 development and progression to the most severe forms. We characterize the differences between adequate innate and adaptive immune response in mild disease and the deep immune dysfunction in the severe multiorgan disease. The similarities of the human immune response to SARS-CoV-2 and the SARS-CoV and MERS-CoV are underlined. We also summarize known and potential SARS-CoV-2 receptors on epithelial barriers, immune cells, endothelium and clinically involved organs such as lung, gut, kidney, cardiovascular, and neuronal system. Finally, we discuss the known and potential mechanisms underlying the involvement of comorbidities, gender, and age in development of COVID-19. Consequently, we highlight the knowledge gaps and urgent research requirements to provide a quick roadmap for ongoing and needed COVID-19 studies.
AB - With the worldwide spread of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) resulting in declaration of a pandemic by the World Health Organization (WHO) on March 11, 2020, the SARS-CoV-2-induced coronavirus disease-19 (COVID-19) has become one of the main challenges of our times. The high infection rate and the severe disease course led to major safety and social restriction measures worldwide. There is an urgent need of unbiased expert knowledge guiding the development of efficient treatment and prevention strategies. This report summarizes current immunological data on mechanisms associated with the SARS-CoV-2 infection and COVID-19 development and progression to the most severe forms. We characterize the differences between adequate innate and adaptive immune response in mild disease and the deep immune dysfunction in the severe multiorgan disease. The similarities of the human immune response to SARS-CoV-2 and the SARS-CoV and MERS-CoV are underlined. We also summarize known and potential SARS-CoV-2 receptors on epithelial barriers, immune cells, endothelium and clinically involved organs such as lung, gut, kidney, cardiovascular, and neuronal system. Finally, we discuss the known and potential mechanisms underlying the involvement of comorbidities, gender, and age in development of COVID-19. Consequently, we highlight the knowledge gaps and urgent research requirements to provide a quick roadmap for ongoing and needed COVID-19 studies.
KW - COVID-19 comorbidity
KW - COVID-19 immunity
KW - COVID-19 multimorbidity
KW - COVID-19 prevention
KW - COVID-19 treatment
KW - SARS
KW - SARS-CoV-2 receptors
UR - http://www.scopus.com/inward/record.url?scp=85088253490&partnerID=8YFLogxK
U2 - 10.1111/all.14462
DO - 10.1111/all.14462
M3 - Article
C2 - 32584441
AN - SCOPUS:85088253490
SN - 0105-4538
VL - 75
SP - 2445
EP - 2476
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 10
ER -