Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma

Maximilian Erlmeier; Marie Mikuteit; Stefanie Zschäbitz; Michael Autenrieth; Wilko Weichert; Arndt Hartmann; Sandra Steffens; Franziska Erlmeier

doi:10.1186/s12894-023-01263-0

Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma

Maximilian Erlmeier, Marie Mikuteit, Stefanie Zschäbitz, Michael Autenrieth, Wilko Weichert, Arndt Hartmann, Sandra Steffens, Franziska Erlmeier

Chair of Pathology

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Abstract

Background: The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). Methods: Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. Results: 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF⁻ compared to HGF⁺ tumors (95.0% versus 90.9%; p = 0.410). Conclusions: In chRCC HGF expression is not associated with parameters of aggressiveness or survival.

Original language	English
Article number	90
Journal	BMC Urology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12894-023-01263-0
State	Published - Dec 2023

Keywords

Chromophobe histology
HGF
Renal Cell Carcinoma
Survival

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10.1186/s12894-023-01263-0

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@article{82556ffddfe44e2ea9c717187582f560,

title = "Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma",

abstract = "Background: The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). Methods: Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. Results: 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF− compared to HGF+ tumors (95.0% versus 90.9%; p = 0.410). Conclusions: In chRCC HGF expression is not associated with parameters of aggressiveness or survival.",

keywords = "Chromophobe histology, HGF, Renal Cell Carcinoma, Survival",

author = "Maximilian Erlmeier and Marie Mikuteit and Stefanie Zsch{\"a}bitz and Michael Autenrieth and Wilko Weichert and Arndt Hartmann and Sandra Steffens and Franziska Erlmeier",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = dec,

doi = "10.1186/s12894-023-01263-0",

language = "English",

volume = "23",

journal = "BMC Urology",

issn = "1471-2490",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma

AU - Erlmeier, Maximilian

AU - Mikuteit, Marie

AU - Zschäbitz, Stefanie

AU - Autenrieth, Michael

AU - Weichert, Wilko

AU - Hartmann, Arndt

AU - Steffens, Sandra

AU - Erlmeier, Franziska

PY - 2023/12

Y1 - 2023/12

N2 - Background: The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). Methods: Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. Results: 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF− compared to HGF+ tumors (95.0% versus 90.9%; p = 0.410). Conclusions: In chRCC HGF expression is not associated with parameters of aggressiveness or survival.

AB - Background: The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). Methods: Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. Results: 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF− compared to HGF+ tumors (95.0% versus 90.9%; p = 0.410). Conclusions: In chRCC HGF expression is not associated with parameters of aggressiveness or survival.

KW - Chromophobe histology

KW - HGF

KW - Renal Cell Carcinoma

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85159229780&partnerID=8YFLogxK

U2 - 10.1186/s12894-023-01263-0

DO - 10.1186/s12894-023-01263-0

M3 - Article

C2 - 37170275

AN - SCOPUS:85159229780

SN - 1471-2490

VL - 23

JO - BMC Urology

JF - BMC Urology

IS - 1

M1 - 90

ER -

Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma

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