TY - JOUR
T1 - Immunohistochemical analysis of procathepsin L and cathepsin B in cutaneous Kaposi's sarcoma
AU - Thewes, Matthias
AU - Engst, Reinhard
AU - Jürgens, Maren
AU - Borelli, Siegfried
PY - 1997/2
Y1 - 1997/2
N2 - Background: The expression of the proteinases cathepsins L and B are induced in tumors by malignant transformation, growth factors, and tumor promoters suggesting they play an important role in tumor invasion and metastasis. Methods: By immunohistochemistry, procathepsin L and cathepsin B were studied in patients with Kaposi's sarcoma (KS). Formalin-fixed and paraffin-embedded tissues from 29 cases of KS (AIDS-associated KS, n = 24; non-AIDS-associated KS, n = 5) were immunolabeled with the polyclonal antibody directed against procathepsin L and the antisera directed against cathepsin B. Results: Normal epidermis, eccrine sweat glands, and hair follicle expressed both cathepsins. We also found a positive staining for procathepsin L in normal blood vessels. In both 'angiomatous and 'fibroblastic' lesions of KS no expression of these enzymes was observed. Conclusions: These findings support the hypothesis of a benign autochthonous origin of the lesions, such as a hyperplasia.
AB - Background: The expression of the proteinases cathepsins L and B are induced in tumors by malignant transformation, growth factors, and tumor promoters suggesting they play an important role in tumor invasion and metastasis. Methods: By immunohistochemistry, procathepsin L and cathepsin B were studied in patients with Kaposi's sarcoma (KS). Formalin-fixed and paraffin-embedded tissues from 29 cases of KS (AIDS-associated KS, n = 24; non-AIDS-associated KS, n = 5) were immunolabeled with the polyclonal antibody directed against procathepsin L and the antisera directed against cathepsin B. Results: Normal epidermis, eccrine sweat glands, and hair follicle expressed both cathepsins. We also found a positive staining for procathepsin L in normal blood vessels. In both 'angiomatous and 'fibroblastic' lesions of KS no expression of these enzymes was observed. Conclusions: These findings support the hypothesis of a benign autochthonous origin of the lesions, such as a hyperplasia.
UR - http://www.scopus.com/inward/record.url?scp=0030898627&partnerID=8YFLogxK
U2 - 10.1046/j.1365-4362.1997.00005.x
DO - 10.1046/j.1365-4362.1997.00005.x
M3 - Article
C2 - 9109004
AN - SCOPUS:0030898627
SN - 0011-9059
VL - 36
SP - 100
EP - 103
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 2
ER -
