Immunogenic Reaction of Implanted Biomaterials from Nature

Martijn Van Griensven, Elizabeth Rosado Balmayor

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Biomaterials are implanted in organisms in an array of different tissues and for the purpose of several applications. This will always lead to local tissue injury and an interaction of the biomaterial with the surrounding tissues. Moreover, vascular injury is also present. This results in a contact of the biomaterial with the blood coming from the disrupted vessels. Both in the tissues as well as in the blood, immunologic active cells are present. Depending on the material, a minimal or stronger immunological reaction will occur. This chapter deals with these immunogenic reactions to implanted natural biomaterials. The immunogenic reaction is part of the biocompatible properties of a biomaterial. Collagen can be applied or administered in different forms such as sponges, powder, films etc. Sponges are used in an array of different applications in surgery from orthopedic-trauma to odontology. Chitosan has been extensively proposed in the biomedical arena for bone cartilage and skin-related applications.

Original languageEnglish
Title of host publicationBiomaterials from Nature for Advanced Devices and Therapies
PublisherWiley Blackwell
Number of pages15
ISBN (Electronic)9781119126218
ISBN (Print)9781118478059
StatePublished - 1 Jan 2016
Externally publishedYes


  • Bone cartilage
  • Chitosan
  • Collagen
  • Immunogenic reaction
  • Natural biomaterials
  • Odontology
  • Orthopedic-trauma
  • Skin-related applications
  • Vascular injury


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