Immunoenzymatic determination of atrazine in rat tissue samples

Brigitte Scutaru, Thomas Giersch, Carmen Cozmei, Berthold Hock

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


In the present study our objective was to adapt a competitive enzyme immunoassay (EIA) for the determination of atrazine in animal tissues (liver and kidney). Female Wistar rats were administered through gavage with a single dose of atrazine (500 or 1000 mg/kg body weight) and sacrificed 24, 48 h and 7 days following the exposure. Using liver tissue samples the extraction procedure was improved. The atrazine concentrations measured in the liver were higher than those found in the kidney, but both can be ranked as low compared with the amount of the administered doses. These data confirm that tissue retention is minimal. Further studies are necessary in order to make an overall evaluation concerning the amount of atrazine retained in the organism. We consider that the competitive EIA may be a promising technique for epidemiological screening of pesticides.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
Issue number1-3
StatePublished - 15 May 1998


  • Atrazine
  • Immunoassay
  • Rats
  • Tissue samples


Dive into the research topics of 'Immunoenzymatic determination of atrazine in rat tissue samples'. Together they form a unique fingerprint.

Cite this