TY - JOUR
T1 - Immunocytochemistry in adrenocortical tumours
T2 - A clinicomorphological study of 72 neoplasms
AU - Schröder, Sören
AU - Padberg, Barbara Christina
AU - Achilles, Eike
AU - Holl, Konstanze
AU - Dralle, Henning
AU - Klöppel, Günter
PY - 1992/1
Y1 - 1992/1
N2 - Surgical specimens of 72 adrenocortical tumours (ACTs) were investigated. Histologically, 57 tumours were classified as adenomas and 15 as carcinomas. In 9 of the latter cases, distant metastases and/or lethal outcome of disease was recorded. Immunocytochemistry showed only 2 ACTs to be positive for cytokeratin and 6 for vimentin. None of the 72 tumours showed argyrophilia or immunoreactivity for epithelial membrane antigen (EMA), S-100 protein, chromogranin A, Leu 7 or Leu-M1, while 31 cases exhibited positivity on inimunostaining with a polyclonal antiserum against synaptophysin. All 72 ACTs were immunoreactive with the recently described antibody D11. Thus the panel of antibodies described here could not discriminate between adenomas and carcinomas or between carcinomas with aggressive and indolent behaviour. Immunostaining with D11 and for EMA and Leu-M1 may help to distinguish ACTs from phenotypically similar lesions of different histogenesis.
AB - Surgical specimens of 72 adrenocortical tumours (ACTs) were investigated. Histologically, 57 tumours were classified as adenomas and 15 as carcinomas. In 9 of the latter cases, distant metastases and/or lethal outcome of disease was recorded. Immunocytochemistry showed only 2 ACTs to be positive for cytokeratin and 6 for vimentin. None of the 72 tumours showed argyrophilia or immunoreactivity for epithelial membrane antigen (EMA), S-100 protein, chromogranin A, Leu 7 or Leu-M1, while 31 cases exhibited positivity on inimunostaining with a polyclonal antiserum against synaptophysin. All 72 ACTs were immunoreactive with the recently described antibody D11. Thus the panel of antibodies described here could not discriminate between adenomas and carcinomas or between carcinomas with aggressive and indolent behaviour. Immunostaining with D11 and for EMA and Leu-M1 may help to distinguish ACTs from phenotypically similar lesions of different histogenesis.
KW - Adrenal gland
KW - Adrenocortical tumours
KW - Differential diagnosis
KW - Immunocytochemistry
UR - http://www.scopus.com/inward/record.url?scp=0026515474&partnerID=8YFLogxK
U2 - 10.1007/BF01605986
DO - 10.1007/BF01605986
M3 - Article
C2 - 1539453
AN - SCOPUS:0026515474
SN - 0174-7398
VL - 420
SP - 65
EP - 70
JO - Virchows Archiv A Pathological Anatomy and Histopathology
JF - Virchows Archiv A Pathological Anatomy and Histopathology
IS - 1
ER -