Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patients with pancreatic carcinoma

Stefan Thorban; Jürgen D. Roder; Klaus Pantel; J. Rüdiger Siewert

doi:10.1016/S0002-9610(96)00103-1

Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patients with pancreatic carcinoma

Stefan Thorban, Jürgen D. Roder, Klaus Pantel, J. Rüdiger Siewert

Department of Surgery

Research output: Contribution to journal › Article › peer-review

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Abstract

Epithelial cells in the bone marrow of 42 patients with pancreatic carcinoma were identified immunocytochemically with monoclonal antibodies directed to epithelial cytokeratins. The occurrence of tumor relapse in patients who underwent complete surgical resection was significantly associated with cytokeratin-positivity in bone marrow. The presence of these cells is indicative of an increased disseminative capability of the primary tumor and defines a new category of patients for neoadjuvant therapy.

Original language	English
Pages (from-to)	297-298
Number of pages	2
Journal	American Journal of Surgery
Volume	172
Issue number	3
DOIs	https://doi.org/10.1016/S0002-9610(96)00103-1
State	Published - Sep 1996

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title = "Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patients with pancreatic carcinoma",

abstract = "Epithelial cells in the bone marrow of 42 patients with pancreatic carcinoma were identified immunocytochemically with monoclonal antibodies directed to epithelial cytokeratins. The occurrence of tumor relapse in patients who underwent complete surgical resection was significantly associated with cytokeratin-positivity in bone marrow. The presence of these cells is indicative of an increased disseminative capability of the primary tumor and defines a new category of patients for neoadjuvant therapy.",

author = "Stefan Thorban and Roder, {J{\"u}rgen D.} and Klaus Pantel and Siewert, {J. R{\"u}diger}",

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AU - Thorban, Stefan

AU - Roder, Jürgen D.

AU - Pantel, Klaus

AU - Siewert, J. Rüdiger

PY - 1996/9

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N2 - Epithelial cells in the bone marrow of 42 patients with pancreatic carcinoma were identified immunocytochemically with monoclonal antibodies directed to epithelial cytokeratins. The occurrence of tumor relapse in patients who underwent complete surgical resection was significantly associated with cytokeratin-positivity in bone marrow. The presence of these cells is indicative of an increased disseminative capability of the primary tumor and defines a new category of patients for neoadjuvant therapy.

AB - Epithelial cells in the bone marrow of 42 patients with pancreatic carcinoma were identified immunocytochemically with monoclonal antibodies directed to epithelial cytokeratins. The occurrence of tumor relapse in patients who underwent complete surgical resection was significantly associated with cytokeratin-positivity in bone marrow. The presence of these cells is indicative of an increased disseminative capability of the primary tumor and defines a new category of patients for neoadjuvant therapy.

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AN - SCOPUS:0030249273

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ER -

Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patients with pancreatic carcinoma

Abstract

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