Immune Receptor Signaling and the Mushroom Body Mediate Post-ingestion Pathogen Avoidance

Johanna M. Kobler; Francisco J. Rodriguez Jimenez; Irina Petcu; Ilona C. Grunwald Kadow

doi:10.1016/j.cub.2020.09.022

Immune Receptor Signaling and the Mushroom Body Mediate Post-ingestion Pathogen Avoidance

Johanna M. Kobler, Francisco J. Rodriguez Jimenez, Irina Petcu, Ilona C. Grunwald Kadow

Associate Professorship of Neuronal Control of Metabolism

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Kobler et al. unravel a mechanism underpinning acquired avoidance of spoiled food. Flies innately prefer the odor of pathogenic bacteria and readily feed on them. This initial acceptance turns into a lasting feeding suppression after ingestion, a behavioral adaptation that relies on the mushroom body and immune receptors in octopaminergic neurons.

Original language	English
Pages (from-to)	4693-4709.e3
Journal	Current Biology
Volume	30
Issue number	23
DOIs	https://doi.org/10.1016/j.cub.2020.09.022
State	Published - 7 Dec 2020

Keywords

Drosophila
Erwinia carotovora carotovora
Imd signaling
PGRP-LC
Pseudomonas entomophila
feeding behavior
gut-brain
mushroom body
octopamine
olfactory system
pathogen

Access to Document

10.1016/j.cub.2020.09.022

Cite this

@article{6eeafe34fa3740f09cfb57ba943ad27e,

title = "Immune Receptor Signaling and the Mushroom Body Mediate Post-ingestion Pathogen Avoidance",

abstract = "Kobler et al. unravel a mechanism underpinning acquired avoidance of spoiled food. Flies innately prefer the odor of pathogenic bacteria and readily feed on them. This initial acceptance turns into a lasting feeding suppression after ingestion, a behavioral adaptation that relies on the mushroom body and immune receptors in octopaminergic neurons.",

keywords = "Drosophila, Erwinia carotovora carotovora, Imd signaling, PGRP-LC, Pseudomonas entomophila, feeding behavior, gut-brain, mushroom body, octopamine, olfactory system, pathogen",

author = "Kobler, {Johanna M.} and {Rodriguez Jimenez}, {Francisco J.} and Irina Petcu and {Grunwald Kadow}, {Ilona C.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = dec,

day = "7",

doi = "10.1016/j.cub.2020.09.022",

language = "English",

volume = "30",

pages = "4693--4709.e3",

journal = "Current Biology",

issn = "0960-9822",

publisher = "Cell Press",

number = "23",

}

TY - JOUR

T1 - Immune Receptor Signaling and the Mushroom Body Mediate Post-ingestion Pathogen Avoidance

AU - Kobler, Johanna M.

AU - Rodriguez Jimenez, Francisco J.

AU - Petcu, Irina

AU - Grunwald Kadow, Ilona C.

PY - 2020/12/7

Y1 - 2020/12/7

N2 - Kobler et al. unravel a mechanism underpinning acquired avoidance of spoiled food. Flies innately prefer the odor of pathogenic bacteria and readily feed on them. This initial acceptance turns into a lasting feeding suppression after ingestion, a behavioral adaptation that relies on the mushroom body and immune receptors in octopaminergic neurons.

AB - Kobler et al. unravel a mechanism underpinning acquired avoidance of spoiled food. Flies innately prefer the odor of pathogenic bacteria and readily feed on them. This initial acceptance turns into a lasting feeding suppression after ingestion, a behavioral adaptation that relies on the mushroom body and immune receptors in octopaminergic neurons.

KW - Drosophila

KW - Erwinia carotovora carotovora

KW - Imd signaling

KW - PGRP-LC

KW - Pseudomonas entomophila

KW - feeding behavior

KW - gut-brain

KW - mushroom body

KW - octopamine

KW - olfactory system

KW - pathogen

UR - http://www.scopus.com/inward/record.url?scp=85092651188&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2020.09.022

DO - 10.1016/j.cub.2020.09.022

M3 - Article

C2 - 33007248

AN - SCOPUS:85092651188

SN - 0960-9822

VL - 30

SP - 4693-4709.e3

JO - Current Biology

JF - Current Biology

IS - 23

ER -

Immune Receptor Signaling and the Mushroom Body Mediate Post-ingestion Pathogen Avoidance

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this