Immune Receptor Signaling and the Mushroom Body Mediate Post-ingestion Pathogen Avoidance

Johanna M. Kobler, Francisco J. Rodriguez Jimenez, Irina Petcu, Ilona C. Grunwald Kadow

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Kobler et al. unravel a mechanism underpinning acquired avoidance of spoiled food. Flies innately prefer the odor of pathogenic bacteria and readily feed on them. This initial acceptance turns into a lasting feeding suppression after ingestion, a behavioral adaptation that relies on the mushroom body and immune receptors in octopaminergic neurons.

Original languageEnglish
Pages (from-to)4693-4709.e3
JournalCurrent Biology
Volume30
Issue number23
DOIs
StatePublished - 7 Dec 2020

Keywords

  • Drosophila
  • Erwinia carotovora carotovora
  • Imd signaling
  • PGRP-LC
  • Pseudomonas entomophila
  • feeding behavior
  • gut-brain
  • mushroom body
  • octopamine
  • olfactory system
  • pathogen

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