Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases

Teofila Seremet; Jeremy Di Domizio; Antoine Girardin; Ahmad Yatim; Raphael Jenelten; Francesco Messina; Fanny Saidoune; Christoph Schlapbach; Sofia Bogiatzi; Frederic Minisini; Natalie Garzorz-Stark; Matthieu Leuenberger; Héloise Wüthrich; Maxime Vernez; Daniel Hohl; Stefanie Eyerich; Kilian Eyerich; Emmanuella Guenova; Carle Paul; Raphael Gottardo; Curdin Conrad; Michel Gilliet

doi:10.1038/s41467-024-54559-6

Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases

Teofila Seremet, Jeremy Di Domizio, Antoine Girardin, Ahmad Yatim, Raphael Jenelten, Francesco Messina, Fanny Saidoune, Christoph Schlapbach, Sofia Bogiatzi, Frederic Minisini, Natalie Garzorz-Stark, Matthieu Leuenberger, Héloise Wüthrich, Maxime Vernez, Daniel Hohl, Stefanie Eyerich, Kilian Eyerich, Emmanuella Guenova, Carle Paul, Raphael GottardoCurdin Conrad, Michel Gilliet

Research output: Contribution to journal › Article › peer-review

Abstract

Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with treatment targets offers a rational framework for treatment selection, improving response rates in both treatment-naïve patients and non-responders to targeted therapies. Overall, our approach offers precision medicine for inflammatory skin diseases, utilizing transcriptional modules to support diagnosis and guide personalized treatment selection.

Original language	English
Article number	10688
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-54559-6
State	Published - Dec 2024
Externally published	Yes

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Seremet, T., Di Domizio, J., Girardin, A., Yatim, A., Jenelten, R., Messina, F., Saidoune, F., Schlapbach, C., Bogiatzi, S., Minisini, F., Garzorz-Stark, N., Leuenberger, M., Wüthrich, H., Vernez, M., Hohl, D., Eyerich, S., Eyerich, K., Guenova, E., Paul, C., ... Gilliet, M. (2024). Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases. Nature Communications, 15(1), Article 10688. https://doi.org/10.1038/s41467-024-54559-6

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title = "Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases",

abstract = "Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with treatment targets offers a rational framework for treatment selection, improving response rates in both treatment-na{\"i}ve patients and non-responders to targeted therapies. Overall, our approach offers precision medicine for inflammatory skin diseases, utilizing transcriptional modules to support diagnosis and guide personalized treatment selection.",

author = "Teofila Seremet and {Di Domizio}, Jeremy and Antoine Girardin and Ahmad Yatim and Raphael Jenelten and Francesco Messina and Fanny Saidoune and Christoph Schlapbach and Sofia Bogiatzi and Frederic Minisini and Natalie Garzorz-Stark and Matthieu Leuenberger and H{\'e}loise W{\"u}thrich and Maxime Vernez and Daniel Hohl and Stefanie Eyerich and Kilian Eyerich and Emmanuella Guenova and Carle Paul and Raphael Gottardo and Curdin Conrad and Michel Gilliet",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

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doi = "10.1038/s41467-024-54559-6",

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Seremet, T, Di Domizio, J, Girardin, A, Yatim, A, Jenelten, R, Messina, F, Saidoune, F, Schlapbach, C, Bogiatzi, S, Minisini, F, Garzorz-Stark, N, Leuenberger, M, Wüthrich, H, Vernez, M, Hohl, D, Eyerich, S , Eyerich, K, Guenova, E, Paul, C, Gottardo, R, Conrad, C & Gilliet, M 2024, 'Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases', Nature Communications, vol. 15, no. 1, 10688. https://doi.org/10.1038/s41467-024-54559-6

TY - JOUR

T1 - Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases

AU - Seremet, Teofila

AU - Di Domizio, Jeremy

AU - Girardin, Antoine

AU - Yatim, Ahmad

AU - Jenelten, Raphael

AU - Messina, Francesco

AU - Saidoune, Fanny

AU - Schlapbach, Christoph

AU - Bogiatzi, Sofia

AU - Minisini, Frederic

AU - Garzorz-Stark, Natalie

AU - Leuenberger, Matthieu

AU - Wüthrich, Héloise

AU - Vernez, Maxime

AU - Hohl, Daniel

AU - Eyerich, Stefanie

AU - Eyerich, Kilian

AU - Guenova, Emmanuella

AU - Paul, Carle

AU - Gottardo, Raphael

AU - Conrad, Curdin

AU - Gilliet, Michel

PY - 2024/12

Y1 - 2024/12

N2 - Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with treatment targets offers a rational framework for treatment selection, improving response rates in both treatment-naïve patients and non-responders to targeted therapies. Overall, our approach offers precision medicine for inflammatory skin diseases, utilizing transcriptional modules to support diagnosis and guide personalized treatment selection.

AB - Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with treatment targets offers a rational framework for treatment selection, improving response rates in both treatment-naïve patients and non-responders to targeted therapies. Overall, our approach offers precision medicine for inflammatory skin diseases, utilizing transcriptional modules to support diagnosis and guide personalized treatment selection.

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SN - 2041-1723

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JO - Nature Communications

JF - Nature Communications

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ER -

Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases

Abstract

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