Immune Biology and Persistence of Helicobacter pylori in Gastric Diseases

Sonja Fuchs, Ruolan Gong, Markus Gerhard, Raquel Mejías-Luque

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Helicobacter pylori is a prevalent pathogen, which affects more than 40% of the global population. It colonizes the human stomach and persists in its host for several decades or even a lifetime, if left untreated. The persistent infection has been linked to various gastric diseases, including gastritis, peptic ulcers, and an increased risk for gastric cancer. H. pylori infection triggers a strong immune response directed against the bacterium associated with the infiltration of innate phagocytotic immune cells and the induction of a Th1/Th17 response. Even though certain immune cells seem to be capable of controlling the infection, the host is unable to eliminate the bacteria as H. pylori has developed remarkable immune evasion strategies. The bacterium avoids its killing through innate recognition mechanisms and manipulates gastric epithelial cells and immune cells to support its persistence. This chapter focuses on the innate and adaptive immune response induced by H. pylori infection, and immune evasion strategies employed by the bacterium to enable persistent infection.

Original languageEnglish
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Science and Business Media Deutschland GmbH
Pages83-115
Number of pages33
DOIs
StatePublished - 2023

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume444
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

Keywords

  • H. pylori
  • Immune evasion
  • Immune response
  • Persistence

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