Immundefekte bei chronischer Rhinosinusitis: Eine bedeutende und oft unterschätzte Ursache

L. Klimek; A. Chaker; C. Matthias; A. Sperl; P. Gevaert; P. Hellings; B. Wollenberg; M. Koennecke; J. Hagemann; J. Eckrich; S. Becker

doi:10.1007/s00106-019-0719-2

Immundefekte bei chronischer Rhinosinusitis: Eine bedeutende und oft unterschätzte Ursache

Translated title of the contribution: Immunodeficiency in chronic rhinosinusitis: An important and often underestimated cause

L. Klimek
, A. Chaker
, C. Matthias
, A. Sperl
, P. Gevaert
, P. Hellings
, B. Wollenberg
, M. Koennecke
, J. Hagemann
, J. Eckrich
, S. Becker

Zentrum für Allergologie und Rhinologie Wiesbaden
Technical University of Munich
University Medical Center
Ghent University Hospital
Katholieke Universiteit Leuven
Universitätsklinikum Schleswig-Holstein Campus Lübeck
Universitätsklinikum Tübingen

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Chronic rhinosinusitis (CRS) is one of the most frequent chronic diseases. Among these patients the prevalence of immune defects is higher than in the healthy general population. Methods: A selective review of the literature was carried out in PubMed and Medline covering the period between 2008 and 2019. Additionally, recent German publications in journals not listed in the abovementioned databases were analyzed. Results: The diagnostic workflow with respect to the immunodeficiency consists of a detailed anamnesis and physical examination, laboratory tests and the antibody reaction to polysaccharide vaccines and antigens. Beside antibiotic treatment, vaccinations and immunoglobulin replacement are available. Notwithstanding the above, functional endoscopic surgery of the paranasal sinuses should be performed according to guideline recommendations. Conclusion: Patients with CRS who do not sufficiently respond to conservative and surgical treatment should be checked for underlying immunodeficiencies.

Translated title of the contribution	Immunodeficiency in chronic rhinosinusitis: An important and often underestimated cause
Original language	German
Pages (from-to)	715-730
Number of pages	16
Journal	HNO
Volume	67
Issue number	9
DOIs	https://doi.org/10.1007/s00106-019-0719-2
State	Published - 1 Sep 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/s00106-019-0719-2

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@article{11b032256f1344dda559e9e427490b8f,

title = "Immundefekte bei chronischer Rhinosinusitis: Eine bedeutende und oft untersch{\"a}tzte Ursache",

abstract = "Background: Chronic rhinosinusitis (CRS) is one of the most frequent chronic diseases. Among these patients the prevalence of immune defects is higher than in the healthy general population. Methods: A selective review of the literature was carried out in PubMed and Medline covering the period between 2008 and 2019. Additionally, recent German publications in journals not listed in the abovementioned databases were analyzed. Results: The diagnostic workflow with respect to the immunodeficiency consists of a detailed anamnesis and physical examination, laboratory tests and the antibody reaction to polysaccharide vaccines and antigens. Beside antibiotic treatment, vaccinations and immunoglobulin replacement are available. Notwithstanding the above, functional endoscopic surgery of the paranasal sinuses should be performed according to guideline recommendations. Conclusion: Patients with CRS who do not sufficiently respond to conservative and surgical treatment should be checked for underlying immunodeficiencies.",

keywords = "Common variable immunodeficiency, Immunoglobulins, Nasal mucosa, Paranasal sinuses, Specific antibody deficiency",

author = "L. Klimek and A. Chaker and C. Matthias and A. Sperl and P. Gevaert and P. Hellings and B. Wollenberg and M. Koennecke and J. Hagemann and J. Eckrich and S. Becker",

note = "Publisher Copyright: {\textcopyright} 2019, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.",

year = "2019",

month = sep,

day = "1",

doi = "10.1007/s00106-019-0719-2",

language = "Deutsch",

volume = "67",

pages = "715--730",

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TY - JOUR

T1 - Immundefekte bei chronischer Rhinosinusitis

T2 - Eine bedeutende und oft unterschätzte Ursache

AU - Klimek, L.

AU - Chaker, A.

AU - Matthias, C.

AU - Sperl, A.

AU - Gevaert, P.

AU - Hellings, P.

AU - Wollenberg, B.

AU - Koennecke, M.

AU - Hagemann, J.

AU - Eckrich, J.

AU - Becker, S.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Background: Chronic rhinosinusitis (CRS) is one of the most frequent chronic diseases. Among these patients the prevalence of immune defects is higher than in the healthy general population. Methods: A selective review of the literature was carried out in PubMed and Medline covering the period between 2008 and 2019. Additionally, recent German publications in journals not listed in the abovementioned databases were analyzed. Results: The diagnostic workflow with respect to the immunodeficiency consists of a detailed anamnesis and physical examination, laboratory tests and the antibody reaction to polysaccharide vaccines and antigens. Beside antibiotic treatment, vaccinations and immunoglobulin replacement are available. Notwithstanding the above, functional endoscopic surgery of the paranasal sinuses should be performed according to guideline recommendations. Conclusion: Patients with CRS who do not sufficiently respond to conservative and surgical treatment should be checked for underlying immunodeficiencies.

AB - Background: Chronic rhinosinusitis (CRS) is one of the most frequent chronic diseases. Among these patients the prevalence of immune defects is higher than in the healthy general population. Methods: A selective review of the literature was carried out in PubMed and Medline covering the period between 2008 and 2019. Additionally, recent German publications in journals not listed in the abovementioned databases were analyzed. Results: The diagnostic workflow with respect to the immunodeficiency consists of a detailed anamnesis and physical examination, laboratory tests and the antibody reaction to polysaccharide vaccines and antigens. Beside antibiotic treatment, vaccinations and immunoglobulin replacement are available. Notwithstanding the above, functional endoscopic surgery of the paranasal sinuses should be performed according to guideline recommendations. Conclusion: Patients with CRS who do not sufficiently respond to conservative and surgical treatment should be checked for underlying immunodeficiencies.

KW - Common variable immunodeficiency

KW - Immunoglobulins

KW - Nasal mucosa

KW - Paranasal sinuses

KW - Specific antibody deficiency

UR - https://www.scopus.com/pages/publications/85070811297

U2 - 10.1007/s00106-019-0719-2

DO - 10.1007/s00106-019-0719-2

M3 - Artikel

C2 - 31407017

AN - SCOPUS:85070811297

SN - 0017-6192

VL - 67

SP - 715

EP - 730

JO - HNO

JF - HNO

IS - 9

ER -

Immundefekte bei chronischer Rhinosinusitis: Eine bedeutende und oft unterschätzte Ursache

Abstract

UN SDGs

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