TY - JOUR
T1 - Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using 68Ga-FAPI-04
AU - Notohamiprodjo, Susan
AU - Nekolla, Stephan G.
AU - Robu, Stephanie
AU - Villagran Asiares, Alberto
AU - Kupatt, Christian
AU - Ibrahim, Tareq
AU - Laugwitz, Karl Ludwig
AU - Makowski, Marcus R.
AU - Schwaiger, Markus
AU - Weber, Wolfgang A.
AU - Varasteh, Zohreh
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2022/10
Y1 - 2022/10
N2 - Our previous study has demonstrated the feasibility of noninvasive imaging of fibroblast activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory in a rat model with 68Ga-FAPI-04-PET. In the current extended clinical case, we sought to delineate cardiac uptake of 68Ga-FAPI-04 in a patient after MI with clinical indication for the evidence of fibroblast activation. Carcinoma patients without cardiac disease underwent 68Ga-FAPI-04-PET/CT as control. The patient with one-vessel disease underwent dynamic 68Ga-FAPI-04-cardiac-PET/CMR for 60 minutes. Correlation of cardiac 68Ga-FAPI-04 uptake with clinical findings, ECG, echocardiography, coronary-arteriography and enhanced cardiac-MRI with T1 MOLLI and ECV mapping were performed. No uptake was found in normal myocardium and in mature scar. A focal intense 68Ga-FAPI-04 uptake with continuous wash-out in the infarct territory of coronary occlusion correlating with T1 and ECV mapping was observed. The uptake of 68Ga-FAPI-04 extends beyond the actual infarcted area and overestimates the infarct size as confirmed by follow-up CMR.
AB - Our previous study has demonstrated the feasibility of noninvasive imaging of fibroblast activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory in a rat model with 68Ga-FAPI-04-PET. In the current extended clinical case, we sought to delineate cardiac uptake of 68Ga-FAPI-04 in a patient after MI with clinical indication for the evidence of fibroblast activation. Carcinoma patients without cardiac disease underwent 68Ga-FAPI-04-PET/CT as control. The patient with one-vessel disease underwent dynamic 68Ga-FAPI-04-cardiac-PET/CMR for 60 minutes. Correlation of cardiac 68Ga-FAPI-04 uptake with clinical findings, ECG, echocardiography, coronary-arteriography and enhanced cardiac-MRI with T1 MOLLI and ECV mapping were performed. No uptake was found in normal myocardium and in mature scar. A focal intense 68Ga-FAPI-04 uptake with continuous wash-out in the infarct territory of coronary occlusion correlating with T1 and ECV mapping was observed. The uptake of 68Ga-FAPI-04 extends beyond the actual infarcted area and overestimates the infarct size as confirmed by follow-up CMR.
KW - CAD
KW - PET
KW - diagnostic and prognostic application
KW - hybrid imaging
KW - molecular imaging agents
KW - myocardial ischemia and infarction
UR - http://www.scopus.com/inward/record.url?scp=85104312029&partnerID=8YFLogxK
U2 - 10.1007/s12350-021-02603-z
DO - 10.1007/s12350-021-02603-z
M3 - Article
C2 - 33860458
AN - SCOPUS:85104312029
SN - 1071-3581
VL - 29
SP - 2254
EP - 2261
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 5
ER -