TY - JOUR
T1 - Imaging functional activation of the auditory cortex during focal repetitive transcranial magnetic stimulation of the primary motor cortex in normal subjects
AU - Siebner, Hartwig Roman
AU - Peller, Martin
AU - Willoch, Frode
AU - Auer, Carola
AU - Bartenstein, Peter
AU - Drzezga, Alexander
AU - Schwaiger, Markus
AU - Conrad, Bastian
PY - 1999/7/23
Y1 - 1999/7/23
N2 - Positron emission tomography (PET) during focal repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising approach to study cortical connectivity in awake humans. However, the noise caused by the discharging magnetic coil might have confounding effects on the rTMS-related cortical activation pattern. In twelve healthy volunteers, 18-fluoro-2- deoxy-D-glucose (18FDG) PET was employed to visualize the functional activation of the primary auditory cortex (PAC) during 2 Hz rTMS of the left primary sensorimotor hand area. Magnetic stimuli (1800) were applied at an intensity of 140% of motor resting threshold during the uptake period of 18FDG. Though all subjects wore earplugs, rTMS-related noise induced a consistent bilateral increase of regional glucose utilization in the PAC (P < 0.05, corrected). Thus, rTMS-related acoustic input needs to be taken into account in combined rTMS/PET studies.
AB - Positron emission tomography (PET) during focal repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising approach to study cortical connectivity in awake humans. However, the noise caused by the discharging magnetic coil might have confounding effects on the rTMS-related cortical activation pattern. In twelve healthy volunteers, 18-fluoro-2- deoxy-D-glucose (18FDG) PET was employed to visualize the functional activation of the primary auditory cortex (PAC) during 2 Hz rTMS of the left primary sensorimotor hand area. Magnetic stimuli (1800) were applied at an intensity of 140% of motor resting threshold during the uptake period of 18FDG. Though all subjects wore earplugs, rTMS-related noise induced a consistent bilateral increase of regional glucose utilization in the PAC (P < 0.05, corrected). Thus, rTMS-related acoustic input needs to be taken into account in combined rTMS/PET studies.
KW - Auditory cortex
KW - Functional brain activation
KW - Human
KW - Positron emission tomography
KW - Primary motor cortex
KW - Regional cerebral glucose metabolism
KW - Repetitive transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=0033597967&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(99)00454-1
DO - 10.1016/S0304-3940(99)00454-1
M3 - Article
C2 - 10454140
AN - SCOPUS:0033597967
SN - 0304-3940
VL - 270
SP - 37
EP - 40
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -