Image reconstruction in cross-sectional optoacoustic tomography based on non-negative constrained model-based inversion

Lu Ding, Xose Luís Deán-Ben, Christian Lutzweiler, Daniel Razansky, Vasilis Ntziachristos

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Scopus citations

Abstract

In optoacoustic tomography, images representing the light absorption distribution are reconstructed from the measured acoustic pressure waves at several locations around the imaged sample. Most reconstruction algorithms typically yield negative absorption values due to modelling inaccuracies and imperfect measurement conditions. Those negative optical absorption values have no physical meaning and their presence hinders image quantification and interpretation of biological information. We investigate herein the performance of optimization methods that impose non-negative constraints in model-based optoacoustic inversion. Specifically, we analyze the effects of the non-negative restrictions on image quality and accuracy as compared to the unconstrained approach. An efficient algorithm based on the projected quasi-Newton scheme and the limitedmemory Broyden-Fletcher-Goldfarb-Shannon method is used for the non-negative constrained inversion. We showcase that imposing non-negative constraints in model-based reconstruction leads to a quality increase in cross-sectional tomographic optoacoustic images.

Original languageEnglish
Title of host publicationOpto-Acoustic Methods and Applications in Biophotonics II
EditorsRoger Zemp, Vasilis Ntziachristos
PublisherSPIE
ISBN (Electronic)9781628417043
DOIs
StatePublished - 2015
EventOpto-Acoustic Methods and Applications in Biophotonics II - Munich, Germany
Duration: 22 Jun 201523 Jun 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9539
ISSN (Print)1605-7422

Conference

ConferenceOpto-Acoustic Methods and Applications in Biophotonics II
Country/TerritoryGermany
CityMunich
Period22/06/1523/06/15

Keywords

  • Model-based inversion
  • Non-negative constrained least squares
  • Optoacoustic tomography
  • Photoacoustic tomography

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