TY - JOUR
T1 - Image-Guided Surgery
T2 - Are We Getting the Most out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?
AU - Hensbergen, Albertus Wijnand
AU - Van Willigen, Danny M.
AU - Van Beurden, Florian
AU - Van Leeuwen, Pim J.
AU - Buckle, Tessa
AU - Schottelius, Margret
AU - Maurer, Tobias
AU - Wester, Hans Jürgen
AU - Van Leeuwen, Fijs W.B.
N1 - Publisher Copyright:
Copyright © 2019 American Chemical Society.
PY - 2020/2/19
Y1 - 2020/2/19
N2 - Expressed on virtually all prostate cancers and their metastases, the transmembrane protein prostate-specific membrane antigen (PSMA) provides a valuable target for the imaging of prostate cancer. Not only does PSMA provide a target for noninvasive diagnostic imaging, e.g., PSMA-positron emission tomography (PSMA-PET), it can also be used to guide surgical resections of PSMA-positive lesions. The latter characteristic has led to the development of a plethora of PSMA-targeted tracers, i.e., radiolabeled, fluorescent, or hybrid. With image-guided surgery applications in mind, this review discusses these compounds based on clinical need. Here, the focus is on the chemical aspects (e.g., imaging label, spacer moiety, and targeting vector) and their impact on in vitro and in vivo tracer characteristics (e.g., affinity, tumor uptake, and clearance pattern).
AB - Expressed on virtually all prostate cancers and their metastases, the transmembrane protein prostate-specific membrane antigen (PSMA) provides a valuable target for the imaging of prostate cancer. Not only does PSMA provide a target for noninvasive diagnostic imaging, e.g., PSMA-positron emission tomography (PSMA-PET), it can also be used to guide surgical resections of PSMA-positive lesions. The latter characteristic has led to the development of a plethora of PSMA-targeted tracers, i.e., radiolabeled, fluorescent, or hybrid. With image-guided surgery applications in mind, this review discusses these compounds based on clinical need. Here, the focus is on the chemical aspects (e.g., imaging label, spacer moiety, and targeting vector) and their impact on in vitro and in vivo tracer characteristics (e.g., affinity, tumor uptake, and clearance pattern).
UR - http://www.scopus.com/inward/record.url?scp=85078666500&partnerID=8YFLogxK
U2 - 10.1021/acs.bioconjchem.9b00758
DO - 10.1021/acs.bioconjchem.9b00758
M3 - Article
C2 - 31855410
AN - SCOPUS:85078666500
SN - 1043-1802
VL - 31
SP - 375
EP - 395
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 2
ER -
