TY - JOUR
T1 - Image analysis for assessing molecular activity changes in time-dependent geometries
AU - Marias, Kostas
AU - Ripoll, Jörge
AU - Meyer, Heiko
AU - Ntziachristos, Vasilis
AU - Orphanoudakis, Stelios
PY - 2005/7
Y1 - 2005/7
N2 - In vivo fluorescence molecular imaging and tomography has facilitated monitoring of genomics and proteomics over time and on the same animal. A highly important issue, however, has been the robust registration of animals imaged at different time points to obtain accurate description of activity and location. This paper presents a method for aligning temporal data of small animals based on surface anatomical features and improving the accuracy of monitoring fluorophore distribution. The method can account for differences in the positioning and compression of small animals and can be extended to three-dimensional as well as to other imaging modalities.
AB - In vivo fluorescence molecular imaging and tomography has facilitated monitoring of genomics and proteomics over time and on the same animal. A highly important issue, however, has been the robust registration of animals imaged at different time points to obtain accurate description of activity and location. This paper presents a method for aligning temporal data of small animals based on surface anatomical features and improving the accuracy of monitoring fluorophore distribution. The method can account for differences in the positioning and compression of small animals and can be extended to three-dimensional as well as to other imaging modalities.
KW - Image sequence analysis
KW - Optical image processing
KW - Registration
UR - http://www.scopus.com/inward/record.url?scp=23744480995&partnerID=8YFLogxK
U2 - 10.1109/TMI.2005.848612
DO - 10.1109/TMI.2005.848612
M3 - Article
C2 - 16011319
AN - SCOPUS:23744480995
SN - 0278-0062
VL - 24
SP - 894
EP - 900
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
IS - 7
ER -