Image analysis for assessing molecular activity changes in time-dependent geometries

Kostas Marias, Jörge Ripoll, Heiko Meyer, Vasilis Ntziachristos, Stelios Orphanoudakis

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In vivo fluorescence molecular imaging and tomography has facilitated monitoring of genomics and proteomics over time and on the same animal. A highly important issue, however, has been the robust registration of animals imaged at different time points to obtain accurate description of activity and location. This paper presents a method for aligning temporal data of small animals based on surface anatomical features and improving the accuracy of monitoring fluorophore distribution. The method can account for differences in the positioning and compression of small animals and can be extended to three-dimensional as well as to other imaging modalities.

Original languageEnglish
Pages (from-to)894-900
Number of pages7
JournalIEEE Transactions on Medical Imaging
Volume24
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Image sequence analysis
  • Optical image processing
  • Registration

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