TY - JOUR
T1 - IL-17 and IL-22 in immunity
T2 - Driving protection and pathology
AU - Eyerich, Kilian
AU - Dimartino, Valentina
AU - Cavani, Andrea
N1 - Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/4/1
Y1 - 2017/4/1
N2 - IL-17 and IL-22 are tissue-signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro-inflammatory or regenerative potential. An imbalance of the carefully orchestrated tissue-signaling system might result in autoimmune diseases, promote cancer growth, or predispose to infectious diseases. This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double-faceted cytokines IL-17 and IL-22.
AB - IL-17 and IL-22 are tissue-signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro-inflammatory or regenerative potential. An imbalance of the carefully orchestrated tissue-signaling system might result in autoimmune diseases, promote cancer growth, or predispose to infectious diseases. This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double-faceted cytokines IL-17 and IL-22.
KW - Th17
KW - Th22
KW - autoimmune diseases
KW - cytokines
UR - http://www.scopus.com/inward/record.url?scp=85017257071&partnerID=8YFLogxK
U2 - 10.1002/eji.201646723
DO - 10.1002/eji.201646723
M3 - Article
C2 - 28295238
AN - SCOPUS:85017257071
SN - 0014-2980
VL - 47
SP - 607
EP - 614
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 4
ER -
