IL-17 and IL-22 in immunity: Driving protection and pathology

Kilian Eyerich, Valentina Dimartino, Andrea Cavani

Research output: Contribution to journalArticlepeer-review

254 Scopus citations

Abstract

IL-17 and IL-22 are tissue-signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro-inflammatory or regenerative potential. An imbalance of the carefully orchestrated tissue-signaling system might result in autoimmune diseases, promote cancer growth, or predispose to infectious diseases. This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double-faceted cytokines IL-17 and IL-22.

Original languageEnglish
Pages (from-to)607-614
Number of pages8
JournalEuropean Journal of Immunology
Volume47
Issue number4
DOIs
StatePublished - 1 Apr 2017

Keywords

  • Th17
  • Th22
  • autoimmune diseases
  • cytokines

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