Identifikation von hochrisikopatienten nach leichtem schä del-hirn-trauma: Messung des neuroglialen proteins S100

P. Biberthaler; T. Mussack; K. G. Kanz; U. Linsenmaier; K. J. Pfeifer; W. Mutschler; M. Jochum

doi:10.1007/s00113-004-0730-1

Identifikation von hochrisikopatienten nach leichtem schä del-hirn-trauma: Messung des neuroglialen proteins S100

Translated title of the contribution: Identification of high-risk patients after minor craniocerebral trauma. Measurement of nerve tissue protein S100

P. Biberthaler
, T. Mussack
, K. G. Kanz
, U. Linsenmaier
, K. J. Pfeifer
, W. Mutschler
, M. Jochum

University of Munich

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The indication for an initial cranial computed tomography (CCT) in minor head trauma (MHT) patients remains the subject of discussion. The aim of this study was to investigate whether a newly developed, rapid test system (ELECSYS S100, Roche Diagnostics) might allow a diagnostically valid, reproducible measurement of S100 in MHT patients. Blood samples were drawn from 75 MHT patients, a CCT scan was performed, and those with a post-traumatic intracranial lesion counted as CCT+. Results were compared to a healthy control group (n=17). Of the 75 patients included in the study, 14 were stratified as CCT+. The systemic concentration of S100 in these CCT+ patients was significantly increased (0.31 μg/I) compared to the healthy control group (0.04 μg/I) as well as to the CCT-negative patients (0.08 μg/I). The ELECSYS S100 system a allows a rapid, valid, and reproducible assessment of S100B in patient serum and this concentration is significantly elevated in patients suffering from intracranial lesions as shown by initial CCT scan. Hence, this study is the basis for a multicenter trial currently.

Translated title of the contribution	Identification of high-risk patients after minor craniocerebral trauma. Measurement of nerve tissue protein S100
Original language	German
Pages (from-to)	197-202
Number of pages	6
Journal	Unfallchirurg
Volume	107
Issue number	3
DOIs	https://doi.org/10.1007/s00113-004-0730-1
State	Published - Mar 2004
Externally published	Yes

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10.1007/s00113-004-0730-1

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title = "Identifikation von hochrisikopatienten nach leichtem sch{\"a} del-hirn-trauma: Messung des neuroglialen proteins S100",

abstract = "The indication for an initial cranial computed tomography (CCT) in minor head trauma (MHT) patients remains the subject of discussion. The aim of this study was to investigate whether a newly developed, rapid test system (ELECSYS S100, Roche Diagnostics) might allow a diagnostically valid, reproducible measurement of S100 in MHT patients. Blood samples were drawn from 75 MHT patients, a CCT scan was performed, and those with a post-traumatic intracranial lesion counted as CCT+. Results were compared to a healthy control group (n=17). Of the 75 patients included in the study, 14 were stratified as CCT+. The systemic concentration of S100 in these CCT+ patients was significantly increased (0.31 μg/I) compared to the healthy control group (0.04 μg/I) as well as to the CCT-negative patients (0.08 μg/I). The ELECSYS S100 system a allows a rapid, valid, and reproducible assessment of S100B in patient serum and this concentration is significantly elevated in patients suffering from intracranial lesions as shown by initial CCT scan. Hence, this study is the basis for a multicenter trial currently.",

keywords = "CCT, Cranial computed tomography, Minor head trauma, Neurotrauma, S100",

author = "P. Biberthaler and T. Mussack and Kanz, \{K. G.\} and U. Linsenmaier and Pfeifer, \{K. J.\} and W. Mutschler and M. Jochum",

year = "2004",

month = mar,

doi = "10.1007/s00113-004-0730-1",

language = "Deutsch",

volume = "107",

pages = "197--202",

journal = "Unfallchirurg",

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T2 - Messung des neuroglialen proteins S100

AU - Biberthaler, P.

AU - Mussack, T.

AU - Kanz, K. G.

AU - Linsenmaier, U.

AU - Pfeifer, K. J.

AU - Mutschler, W.

AU - Jochum, M.

PY - 2004/3

Y1 - 2004/3

N2 - The indication for an initial cranial computed tomography (CCT) in minor head trauma (MHT) patients remains the subject of discussion. The aim of this study was to investigate whether a newly developed, rapid test system (ELECSYS S100, Roche Diagnostics) might allow a diagnostically valid, reproducible measurement of S100 in MHT patients. Blood samples were drawn from 75 MHT patients, a CCT scan was performed, and those with a post-traumatic intracranial lesion counted as CCT+. Results were compared to a healthy control group (n=17). Of the 75 patients included in the study, 14 were stratified as CCT+. The systemic concentration of S100 in these CCT+ patients was significantly increased (0.31 μg/I) compared to the healthy control group (0.04 μg/I) as well as to the CCT-negative patients (0.08 μg/I). The ELECSYS S100 system a allows a rapid, valid, and reproducible assessment of S100B in patient serum and this concentration is significantly elevated in patients suffering from intracranial lesions as shown by initial CCT scan. Hence, this study is the basis for a multicenter trial currently.

AB - The indication for an initial cranial computed tomography (CCT) in minor head trauma (MHT) patients remains the subject of discussion. The aim of this study was to investigate whether a newly developed, rapid test system (ELECSYS S100, Roche Diagnostics) might allow a diagnostically valid, reproducible measurement of S100 in MHT patients. Blood samples were drawn from 75 MHT patients, a CCT scan was performed, and those with a post-traumatic intracranial lesion counted as CCT+. Results were compared to a healthy control group (n=17). Of the 75 patients included in the study, 14 were stratified as CCT+. The systemic concentration of S100 in these CCT+ patients was significantly increased (0.31 μg/I) compared to the healthy control group (0.04 μg/I) as well as to the CCT-negative patients (0.08 μg/I). The ELECSYS S100 system a allows a rapid, valid, and reproducible assessment of S100B in patient serum and this concentration is significantly elevated in patients suffering from intracranial lesions as shown by initial CCT scan. Hence, this study is the basis for a multicenter trial currently.

KW - CCT

KW - Cranial computed tomography

KW - Minor head trauma

KW - Neurotrauma

KW - S100

UR - https://www.scopus.com/pages/publications/1942424193

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DO - 10.1007/s00113-004-0730-1

M3 - Artikel

C2 - 15042301

AN - SCOPUS:1942424193

SN - 0177-5537

VL - 107

SP - 197

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JO - Unfallchirurg

JF - Unfallchirurg

IS - 3

ER -

Identifikation von hochrisikopatienten nach leichtem schä del-hirn-trauma: Messung des neuroglialen proteins S100

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