Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M

Marion Rusch; Tobias J. Zimmermann; Marco Bürger; Frank J. Dekker; Kristina Görmer; Gemma Triola; Andreas Brockmeyer; Petra Janning; Thomas Böttcher; Stephan A. Sieber; Ingrid R. Vetter; Christian Hedberg; Herbert Waldmann

doi:10.1002/anie.201102967

Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M

Marion Rusch
, Tobias J. Zimmermann
, Marco Bürger
, Frank J. Dekker
, Kristina Görmer
, Gemma Triola
, Andreas Brockmeyer
, Petra Janning
, Thomas Böttcher
, Stephan A. Sieber
, Ingrid R. Vetter
, Christian Hedberg
, Herbert Waldmann

Chair of Organic Chemistry II

Max Planck Inst. fur Molec. Physiol.
pro3dure medical GmbH
University of Groningen
Technical University of Munich

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Finding the target: Activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M (see picture) have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.

Original language	English
Pages (from-to)	9838-9842
Number of pages	5
Journal	Angewandte Chemie International Edition in English
Volume	50
Issue number	42
DOIs	https://doi.org/10.1002/anie.201102967
State	Published - 10 Oct 2011

Keywords

Ras proteins
acyl protein thioesterase
inhibition
proteomics
signal transduction

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10.1002/anie.201102967

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Rusch, M., Zimmermann, T. J., Bürger, M., Dekker, F. J., Görmer, K., Triola, G., Brockmeyer, A., Janning, P., Böttcher, T., Sieber, S. A., Vetter, I. R., Hedberg, C., & Waldmann, H. (2011). Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M. Angewandte Chemie International Edition in English, 50(42), 9838-9842. https://doi.org/10.1002/anie.201102967

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title = "Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M",

abstract = "Finding the target: Activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M (see picture) have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.",

keywords = "Ras proteins, acyl protein thioesterase, inhibition, proteomics, signal transduction",

author = "Marion Rusch and Zimmermann, \{Tobias J.\} and Marco B{\"u}rger and Dekker, \{Frank J.\} and Kristina G{\"o}rmer and Gemma Triola and Andreas Brockmeyer and Petra Janning and Thomas B{\"o}ttcher and Sieber, \{Stephan A.\} and Vetter, \{Ingrid R.\} and Christian Hedberg and Herbert Waldmann",

year = "2011",

month = oct,

day = "10",

doi = "10.1002/anie.201102967",

language = "English",

volume = "50",

pages = "9838--9842",

journal = "Angewandte Chemie International Edition in English",

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Rusch, M, Zimmermann, TJ, Bürger, M, Dekker, FJ, Görmer, K, Triola, G, Brockmeyer, A, Janning, P, Böttcher, T, Sieber, SA, Vetter, IR, Hedberg, C & Waldmann, H 2011, 'Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M', Angewandte Chemie International Edition in English, vol. 50, no. 42, pp. 9838-9842. https://doi.org/10.1002/anie.201102967

TY - JOUR

T1 - Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M

AU - Rusch, Marion

AU - Zimmermann, Tobias J.

AU - Bürger, Marco

AU - Dekker, Frank J.

AU - Görmer, Kristina

AU - Triola, Gemma

AU - Brockmeyer, Andreas

AU - Janning, Petra

AU - Böttcher, Thomas

AU - Sieber, Stephan A.

AU - Vetter, Ingrid R.

AU - Hedberg, Christian

AU - Waldmann, Herbert

PY - 2011/10/10

Y1 - 2011/10/10

N2 - Finding the target: Activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M (see picture) have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.

AB - Finding the target: Activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M (see picture) have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.

KW - Ras proteins

KW - acyl protein thioesterase

KW - inhibition

KW - proteomics

KW - signal transduction

UR - https://www.scopus.com/pages/publications/80053898528

U2 - 10.1002/anie.201102967

DO - 10.1002/anie.201102967

M3 - Article

C2 - 21905186

AN - SCOPUS:80053898528

SN - 1433-7851

VL - 50

SP - 9838

EP - 9842

JO - Angewandte Chemie International Edition in English

JF - Angewandte Chemie International Edition in English

IS - 42

ER -

Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M

Abstract

Keywords

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