Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the ras-signaling modulators palmostatin B and M

Marion Rusch, Tobias J. Zimmermann, Marco Bürger, Frank J. Dekker, Kristina Görmer, Gemma Triola, Andreas Brockmeyer, Petra Janning, Thomas Böttcher, Stephan A. Sieber, Ingrid R. Vetter, Christian Hedberg, Herbert Waldmann

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

Finding the target: Activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M (see picture) have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.

Original languageEnglish
Pages (from-to)9838-9842
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume50
Issue number42
DOIs
StatePublished - 10 Oct 2011

Keywords

  • Ras proteins
  • acyl protein thioesterase
  • inhibition
  • proteomics
  • signal transduction

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