Abstract
The inducible costimulator (ICOS) is a new member of the CD28/CD152 receptor family that regulates T-cell activation and function. ICOS binds to a specific ligand on antigen-presenting cells (APC) and cells of the peripheral tissue different from the CD28/CD152 ligands CD80 and CD86. ICOS-L can be induced by inflammatory stimuli in peripheral tissue and on some APC, including monocytes, but is downregulated in B-cell and myeloid leukemia. ICOS-L delivers distinct signals to T cells, presumably important for the maintenance of certain types of immune response, providing the rationale for the development of new therapeutic strategies for the treatment of diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 91-95 |
| Number of pages | 5 |
| Journal | Onkologie |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2004 |
Keywords
- ICOS
- Ligand/receptor pair, costimulatory
- T-cell activation
