Hypoxia-/HIF-1α-driven factors of the tumor microenvironment impeding antitumor immune responses and promoting malignant progression

Keyphrases

• Hypoxia 100%
• Tumor Microenvironment 100%
• Hypoxia-inducible factor-1α (HIF-1α) 100%
• Antitumor Immune Response 100%
• Malignant Progression 100%
• Immune-suppressive 100%
• CD4+ 25%
• Immune Cells 25%
• Suppression Effect 25%
• Metabolic 25%
• Tumor Treatment 25%
• CD8+ 25%
• Antigen-presenting Cells 25%
• Treg 25%
• Genomic Instability 25%
• Immune Stimulation 25%
• Adenosine 25%
• Oxygen Depletion 25%
• Outer Membrane 25%
• Anticancer Therapy 25%
• Tumor Heterogeneity 25%
• Exosomes 25%
• Downstream Effects 25%
• Vascular Endothelial Growth Factor Receptor (VEGFR) 25%
• Suppressor Cells 25%
• Nutrient Resources 25%
• Immune Suppressor 25%
• Extracellular Acidosis 25%
• Immune Response Inhibition 25%
• Local Suppression 25%
• Anoxia 25%
• Malignant Development 25%
• Phosphatidylserine Externalization 25%
• Lactate Level 25%
• Resistance Development 25%
• Characteristic Traits 25%

Immunology and Microbiology

• Malignant Progression 100%
• Immune Response 100%
• Immunity 100%
• Cytokine 28%
• Regulatory T Cell 14%
• Antigen-Presenting Cell 14%
• Exosome 14%
• CD8 14%
• Immunocompetent Cell 14%
• Secretion (Process) 14%
• Vasculotropin 14%
• Outer Membrane 14%
• CD4 14%
• Membrane Leaflet 14%
• Suppressor Cell 14%

Biochemistry, Genetics and Molecular Biology

• Immune Response 100%
• Immunity 100%
• Cytokine 28%
• Genetics 14%
• Anticancer 14%
• Secretion (Process) 14%
• Antigen Presenting Cell 14%
• Immunocompetent Cell 14%
• Outer Membrane 14%
• Membrane Leaflet 14%
• CD8 14%
• CD4 14%
• Vascular Endothelial Growth Factor 14%
• Phosphatidylserine 14%
• Regulatory T Cell 14%
• Adenosine 14%