Hypopyon after repeated transplantation of human amniotic membrane onto the corneal surface

Bernhard Gabler, Chris P. Lohmann

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Objective: The authors describe a localized probable immunoreaction after repeated transplantation of amniotic membrane (AM) onto the corneal surface. Design: Interventional case report. Intervention: Amniotic membrane was transplanted onto the corneal surface of a 78-year-old female with a deep trophic corneal ulcer resulting in temporary epithelial closure. A second and finally third amniotic membrane transplantation (AMT) was performed because of recurrent ulcerations. All three AMs were obtained from the same donor. Results: The first transplantation of the AM was without complication. However, a hypopyon developed 2 days after the second and 2 days after the third AMT, but the patient responded immediately to topical and systemic corticosteroids. Conclusions: Immunologic, toxic, and hypersensitivity effects could have contributed to the hypopyon iritis that appeared after the second and third AMT, but not after the initial transplantation. In case of a repeated AMT, the use of AM from different donors may help to minimize the risk of an immediate postoperative intraocular inflammation. (C) 2000 by the American Academy of Ophthalmology.

Original languageEnglish
Pages (from-to)1344-1346
Number of pages3
Issue number7
StatePublished - 2000
Externally publishedYes


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