TY - JOUR
T1 - Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper
AU - Bavbek, Sevim
AU - Kepil Özdemir, Seçil
AU - Bonadonna, Patrizia
AU - Atanaskovic-Markovic, Marina
AU - Barbaud, Annick
AU - Brockow, Knut
AU - Laguna Martinez, Jose
AU - Nakonechna, Alla
AU - Pagani, Mauro
AU - Arcolacı, Alessandra
AU - Lombardo, Carla
AU - Torres, Maria J.
N1 - Publisher Copyright:
© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2024/3
Y1 - 2024/3
N2 - Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%–3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic.
AB - Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%–3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic.
KW - allergy
KW - anaphylaxis
KW - drug hypersensitivity
KW - hypersensitivity reaction
KW - proton pump inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85178047809&partnerID=8YFLogxK
U2 - 10.1111/all.15961
DO - 10.1111/all.15961
M3 - Article
C2 - 38013608
AN - SCOPUS:85178047809
SN - 0105-4538
VL - 79
SP - 552
EP - 564
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 3
ER -