Hyperpolarized multi-metal 13C-sensors for magnetic resonance imaging

Anurag Mishra; Giorgio Pariani; Thomas Oerther; Markus Schwaiger; Gil G. Westmeyer

doi:10.1021/acs.analchem.6b03546

Hyperpolarized multi-metal ¹³C-sensors for magnetic resonance imaging

Anurag Mishra, Giorgio Pariani, Thomas Oerther, Markus Schwaiger, Gil G. Westmeyer

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We introduce hyperpolarizable ¹³C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable ¹³C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.

Original language	English
Pages (from-to)	10790-10794
Number of pages	5
Journal	Analytical Chemistry
Volume	88
Issue number	22
DOIs	https://doi.org/10.1021/acs.analchem.6b03546
State	Published - 15 Nov 2016

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abstract = "We introduce hyperpolarizable 13C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable 13C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.",

author = "Anurag Mishra and Giorgio Pariani and Thomas Oerther and Markus Schwaiger and Westmeyer, \{Gil G.\}",

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AU - Pariani, Giorgio

AU - Oerther, Thomas

AU - Schwaiger, Markus

AU - Westmeyer, Gil G.

PY - 2016/11/15

Y1 - 2016/11/15

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AB - We introduce hyperpolarizable 13C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable 13C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.

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Hyperpolarized multi-metal ¹³C-sensors for magnetic resonance imaging

Abstract

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