Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes

A. Raffel; Martin Anlauf; S. B. Hosch; M. Krausch; T. Henopp; J. Bauersfeld; R. Klofat; D. Bach; C. F. Eisenberger; G. Klöppel; W. T. Knoefel; W. T. Knoefel

doi:10.3748/wjg.v12.i44.7221

Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes

A. Raffel, Martin Anlauf, S. B. Hosch, M. Krausch, T. Henopp, J. Bauersfeld, R. Klofat, D. Bach, C. F. Eisenberger, G. Klöppel, W. T. Knoefel, W. T. Knoefel

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In neonates, persistent hyperinsullnemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-dependent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus II has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be considered.

Original language	English
Pages (from-to)	7221-7224
Number of pages	4
Journal	World Journal of Gastroenterology
Volume	12
Issue number	44
DOIs	https://doi.org/10.3748/wjg.v12.i44.7221
State	Published - 28 Nov 2006
Externally published	Yes

Keywords

Adult nesidioblastosis
Diabetes
Hyperinsulinemic hypoglycaemia
Insulinoma
Multiple Endocrine Neoplasia Type 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3748/wjg.v12.i44.7221

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title = "Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes",

abstract = "In neonates, persistent hyperinsullnemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-dependent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus II has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be considered.",

keywords = "Adult nesidioblastosis, Diabetes, Hyperinsulinemic hypoglycaemia, Insulinoma, Multiple Endocrine Neoplasia Type 1",

author = "A. Raffel and Martin Anlauf and Hosch, {S. B.} and M. Krausch and T. Henopp and J. Bauersfeld and R. Klofat and D. Bach and Eisenberger, {C. F.} and G. Kl{\"o}ppel and Knoefel, {W. T.} and Knoefel, {W. T.}",

year = "2006",

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language = "English",

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T1 - Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes

AU - Raffel, A.

AU - Anlauf, Martin

AU - Hosch, S. B.

AU - Krausch, M.

AU - Henopp, T.

AU - Bauersfeld, J.

AU - Klofat, R.

AU - Bach, D.

AU - Eisenberger, C. F.

AU - Klöppel, G.

AU - Knoefel, W. T.

PY - 2006/11/28

Y1 - 2006/11/28

N2 - In neonates, persistent hyperinsullnemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-dependent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus II has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be considered.

AB - In neonates, persistent hyperinsullnemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-dependent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus II has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be considered.

KW - Adult nesidioblastosis

KW - Diabetes

KW - Hyperinsulinemic hypoglycaemia

KW - Insulinoma

KW - Multiple Endocrine Neoplasia Type 1

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U2 - 10.3748/wjg.v12.i44.7221

DO - 10.3748/wjg.v12.i44.7221

M3 - Article

C2 - 17131493

AN - SCOPUS:33845386497

SN - 1007-9327

VL - 12

SP - 7221

EP - 7224

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 44

ER -

Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes

Abstract

Keywords

UN SDGs

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