Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes

A. Raffel, Martin Anlauf, S. B. Hosch, M. Krausch, T. Henopp, J. Bauersfeld, R. Klofat, D. Bach, C. F. Eisenberger, G. Klöppel, W. T. Knoefel, W. T. Knoefel

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12 Scopus citations


In neonates, persistent hyperinsullnemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-dependent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus II has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be considered.

Original languageEnglish
Pages (from-to)7221-7224
Number of pages4
JournalWorld Journal of Gastroenterology
Issue number44
StatePublished - 28 Nov 2006
Externally publishedYes


  • Adult nesidioblastosis
  • Diabetes
  • Hyperinsulinemic hypoglycaemia
  • Insulinoma
  • Multiple Endocrine Neoplasia Type 1


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