Hydroxylation of taurolithocholate by isolated human liver microsomes. I. Identification of metabolic product

D. Trülzsch; J. Roboz; H. Greim; P. Czygan; J. Rudick; F. Hutterer; F. Schaffner; H. Popper

doi:10.1016/0006-2944(74)90048-9

Hydroxylation of taurolithocholate by isolated human liver microsomes. I. Identification of metabolic product

D. Trülzsch, J. Roboz, H. Greim, P. Czygan, J. Rudick, F. Hutterer, F. Schaffner, H. Popper

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Abstract

Human liver microsomes isolated from surgical biopsy specimen hydroxylate taurolithocholic acid in the 6α position. The reaction requires NADPH. The identification of the reaction product as hyodeoxycholic acid is based on data obtained from gas chromatographic, thin-layer chromatographic, and mass spectrometric analyses.

Original language	English
Pages (from-to)	158-166
Number of pages	9
Journal	Biochemical medicine
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0006-2944(74)90048-9
State	Published - Feb 1974
Externally published	Yes

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title = "Hydroxylation of taurolithocholate by isolated human liver microsomes. I. Identification of metabolic product",

abstract = "Human liver microsomes isolated from surgical biopsy specimen hydroxylate taurolithocholic acid in the 6α position. The reaction requires NADPH. The identification of the reaction product as hyodeoxycholic acid is based on data obtained from gas chromatographic, thin-layer chromatographic, and mass spectrometric analyses.",

author = "D. Tr{\"u}lzsch and J. Roboz and H. Greim and P. Czygan and J. Rudick and F. Hutterer and F. Schaffner and H. Popper",

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AU - Trülzsch, D.

AU - Roboz, J.

AU - Greim, H.

AU - Czygan, P.

AU - Rudick, J.

AU - Hutterer, F.

AU - Schaffner, F.

AU - Popper, H.

PY - 1974/2

Y1 - 1974/2

N2 - Human liver microsomes isolated from surgical biopsy specimen hydroxylate taurolithocholic acid in the 6α position. The reaction requires NADPH. The identification of the reaction product as hyodeoxycholic acid is based on data obtained from gas chromatographic, thin-layer chromatographic, and mass spectrometric analyses.

AB - Human liver microsomes isolated from surgical biopsy specimen hydroxylate taurolithocholic acid in the 6α position. The reaction requires NADPH. The identification of the reaction product as hyodeoxycholic acid is based on data obtained from gas chromatographic, thin-layer chromatographic, and mass spectrometric analyses.

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M3 - Article

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AN - SCOPUS:0016029834

SN - 0006-2944

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SP - 158

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JO - Biochemical medicine

JF - Biochemical medicine

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ER -

Hydroxylation of taurolithocholate by isolated human liver microsomes. I. Identification of metabolic product

Abstract

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