Hydroxylation of taurolithocholate by isolated human liver microsomes. I. Identification of metabolic product

D. Trülzsch, J. Roboz, H. Greim, P. Czygan, J. Rudick, F. Hutterer, F. Schaffner, H. Popper

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Human liver microsomes isolated from surgical biopsy specimen hydroxylate taurolithocholic acid in the 6α position. The reaction requires NADPH. The identification of the reaction product as hyodeoxycholic acid is based on data obtained from gas chromatographic, thin-layer chromatographic, and mass spectrometric analyses.

Original languageEnglish
Pages (from-to)158-166
Number of pages9
JournalBiochemical medicine
Volume9
Issue number2
DOIs
StatePublished - Feb 1974
Externally publishedYes

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