Hydroxyl-directed reductive ring opening at the C-2 position of functionalized 2-aryloxetanes

Thorsten Bach, Christian Lange

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

2-Aryloxetanes 3 are cleaved at the C-2 position upon treatment with lithium aluminium hydride to deliver the triols 4 in good yields (61-85 %). The regioselective ring opening at the more hindered position is facilitated by a hydoxyl group attached to the arene.

Original languageEnglish
Pages (from-to)4363-4364
Number of pages2
JournalTetrahedron Letters
Volume37
Issue number25
DOIs
StatePublished - 17 Jun 1996
Externally publishedYes

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