Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA

Laura Tebcharani; Nahida Akter; Di Fan; Oliver Lieleg; Julianne M. Gibbs; Job Boekhoven

doi:10.1039/d3cc00888f

Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA

Laura Tebcharani, Nahida Akter, Di Fan, Oliver Lieleg, Julianne M. Gibbs, Job Boekhoven

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides with a simple, versatile, and cheap platform. Moreover, we combine the platform into a dual-release system that can release a hydrophobic drug with zero-order kinetics, followed by a rapid release of cholesterol-conjugated DNA.

Original language	English
Pages (from-to)	8099-8102
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	52
DOIs	https://doi.org/10.1039/d3cc00888f
State	Published - 23 May 2023

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abstract = "Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides with a simple, versatile, and cheap platform. Moreover, we combine the platform into a dual-release system that can release a hydrophobic drug with zero-order kinetics, followed by a rapid release of cholesterol-conjugated DNA.",

author = "Laura Tebcharani and Nahida Akter and Di Fan and Oliver Lieleg and Gibbs, {Julianne M.} and Job Boekhoven",

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AU - Akter, Nahida

AU - Fan, Di

AU - Lieleg, Oliver

AU - Gibbs, Julianne M.

AU - Boekhoven, Job

PY - 2023/5/23

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AB - Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides with a simple, versatile, and cheap platform. Moreover, we combine the platform into a dual-release system that can release a hydrophobic drug with zero-order kinetics, followed by a rapid release of cholesterol-conjugated DNA.

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VL - 59

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JO - Chemical Communications

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Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA

Abstract

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