Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: A new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins

Sabri Rahmouni; Aaron Lindner; Florian Rechenmacher; Stefanie Neubauer; Tariq Rashad Ali Sobahi; Horst Kessler; Elisabetta Ada Cavalcanti-Adam; Joachim Pius Spatz

doi:10.1002/adma.201301338

Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: A new tool for the measurement of cell traction forces transmitted through α_vβ₃- or α₅β₁-integrins

Sabri Rahmouni, Aaron Lindner, Florian Rechenmacher, Stefanie Neubauer, Tariq Rashad Ali Sobahi, Horst Kessler, Elisabetta Ada Cavalcanti-Adam, Joachim Pius Spatz

TUM Emeriti of Excellence

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α₅ β₁- and α_vβ₃- integrins. Cells adherent via α₅ β₁-integrins have a tendency to exert higher maximum forces than cells adhering via α_vβ₃- integrins.

Original language	English
Pages (from-to)	5869-5874
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	41
DOIs	https://doi.org/10.1002/adma.201301338
State	Published - 6 Nov 2013

Keywords

cell adhesion
integrin
micropillar
peptidomimetics
traction force

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10.1002/adma.201301338

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Rahmouni, S., Lindner, A., Rechenmacher, F., Neubauer, S., Sobahi, T. R. A., Kessler, H., Cavalcanti-Adam, E. A., & Spatz, J. P. (2013). Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: A new tool for the measurement of cell traction forces transmitted through α_vβ₃- or α₅β₁-integrins. Advanced Materials, 25(41), 5869-5874. https://doi.org/10.1002/adma.201301338

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abstract = "Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5 β1- and αvβ3- integrins. Cells adherent via α5 β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3- integrins.",

keywords = "cell adhesion, integrin, micropillar, peptidomimetics, traction force",

author = "Sabri Rahmouni and Aaron Lindner and Florian Rechenmacher and Stefanie Neubauer and Sobahi, {Tariq Rashad Ali} and Horst Kessler and Cavalcanti-Adam, {Elisabetta Ada} and Spatz, {Joachim Pius}",

year = "2013",

month = nov,

day = "6",

doi = "10.1002/adma.201301338",

language = "English",

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Rahmouni, S, Lindner, A, Rechenmacher, F, Neubauer, S, Sobahi, TRA, Kessler, H, Cavalcanti-Adam, EA & Spatz, JP 2013, 'Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: A new tool for the measurement of cell traction forces transmitted through α_vβ₃- or α₅β₁-integrins', Advanced Materials, vol. 25, no. 41, pp. 5869-5874. https://doi.org/10.1002/adma.201301338

Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: A new tool for the measurement of cell traction forces transmitted through α_vβ₃- or α₅β₁-integrins. / Rahmouni, Sabri; Lindner, Aaron; Rechenmacher, Florian et al.
In: Advanced Materials, Vol. 25, No. 41, 06.11.2013, p. 5869-5874.

Research output: Contribution to journal › Article › peer-review

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T1 - Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops

T2 - A new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins

AU - Rahmouni, Sabri

AU - Lindner, Aaron

AU - Rechenmacher, Florian

AU - Neubauer, Stefanie

AU - Sobahi, Tariq Rashad Ali

AU - Kessler, Horst

AU - Cavalcanti-Adam, Elisabetta Ada

AU - Spatz, Joachim Pius

PY - 2013/11/6

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N2 - Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5 β1- and αvβ3- integrins. Cells adherent via α5 β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3- integrins.

AB - Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5 β1- and αvβ3- integrins. Cells adherent via α5 β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3- integrins.

KW - cell adhesion

KW - integrin

KW - micropillar

KW - peptidomimetics

KW - traction force

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JO - Advanced Materials

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IS - 41

ER -

Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: A new tool for the measurement of cell traction forces transmitted through α_vβ₃- or α₅β₁-integrins

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Keywords

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