Hydration Dynamics of Perdeuterated PNIPAM in Aqueous Solution

Christine M. Papadakis; Eric Rende; Feifei Zheng; Bahar Yazdanshenas; Marcell Wolf; Michaela Zamponi; Marie Sousai Appavou; Thomas Müller; Dharani Mullapudi; Alec Nieth; Dirk Schanzenbach; André Laschewsky; Alfons Schulte

doi:10.1021/acs.macromol.5c03241

Hydration Dynamics of Perdeuterated PNIPAM in Aqueous Solution

Christine M. Papadakis
, Eric Rende
, Feifei Zheng
, Bahar Yazdanshenas
, Marcell Wolf
, Michaela Zamponi
, Marie Sousai Appavou
, Thomas Müller
, Dharani Mullapudi
, Alec Nieth
, Dirk Schanzenbach
, André Laschewsky
, Alfons Schulte

Associate Professorship of Experimentalphysik - Weiche Materie

University of Central Florida
Technical University of Munich
Forschungszentrum Jülich (FZJ)
University of Potsdam
Fraunhofer Institut für Angewandte Polymerforschung

Research output: Contribution to journal › Article › peer-review

Abstract

Perdeuterated poly(N-isopropylacrylamide) (PNIPAM-d10) is synthesized by free radical polymerization and characterized by ²H NMR, Fourier-transform infrared, and Raman spectroscopy. A concentrated solution of this polymer in H₂O is investigated with respect to the dynamics of the hydration and bulk water using quasi-elastic neutron scattering. Due to the exchange of the protons in the polymer with deuterons, the incoherent neutron scattering from the polymer is suppressed, offsetting apart the hydration water. Deuteration causes a remarkable upward shift of the cloud point temperature by 4 °C. It is found that, when heating through the cloud point, the fraction of hydration water decreases abruptly. The relaxation time of the hydration water is consistently lower than the one observed previously for PNIPAM in H₂O. Raman spectroscopy of the CD bands across the demixing transition shows a frequency shift consistent with polymer dehydration.

Original language	English
Pages (from-to)	4124-4133
Number of pages	10
Journal	Macromolecules
Volume	59
Issue number	7
DOIs	https://doi.org/10.1021/acs.macromol.5c03241
State	Published - 14 Apr 2026

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@article{c0bd5d3e69914e50bda3a05b2e546a87,

title = "Hydration Dynamics of Perdeuterated PNIPAM in Aqueous Solution",

abstract = "Perdeuterated poly(N-isopropylacrylamide) (PNIPAM-d10) is synthesized by free radical polymerization and characterized by 2H NMR, Fourier-transform infrared, and Raman spectroscopy. A concentrated solution of this polymer in H2O is investigated with respect to the dynamics of the hydration and bulk water using quasi-elastic neutron scattering. Due to the exchange of the protons in the polymer with deuterons, the incoherent neutron scattering from the polymer is suppressed, offsetting apart the hydration water. Deuteration causes a remarkable upward shift of the cloud point temperature by 4 °C. It is found that, when heating through the cloud point, the fraction of hydration water decreases abruptly. The relaxation time of the hydration water is consistently lower than the one observed previously for PNIPAM in H2O. Raman spectroscopy of the CD bands across the demixing transition shows a frequency shift consistent with polymer dehydration.",

author = "Papadakis, \{Christine M.\} and Eric Rende and Feifei Zheng and Bahar Yazdanshenas and Marcell Wolf and Michaela Zamponi and Appavou, \{Marie Sousai\} and Thomas M{\"u}ller and Dharani Mullapudi and Alec Nieth and Dirk Schanzenbach and Andr{\'e} Laschewsky and Alfons Schulte",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors. Published by American Chemical Society",

year = "2026",

month = apr,

day = "14",

doi = "10.1021/acs.macromol.5c03241",

language = "English",

volume = "59",

pages = "4124--4133",

journal = "Macromolecules",

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TY - JOUR

T1 - Hydration Dynamics of Perdeuterated PNIPAM in Aqueous Solution

AU - Papadakis, Christine M.

AU - Rende, Eric

AU - Zheng, Feifei

AU - Yazdanshenas, Bahar

AU - Wolf, Marcell

AU - Zamponi, Michaela

AU - Appavou, Marie Sousai

AU - Müller, Thomas

AU - Mullapudi, Dharani

AU - Nieth, Alec

AU - Schanzenbach, Dirk

AU - Laschewsky, André

AU - Schulte, Alfons

PY - 2026/4/14

Y1 - 2026/4/14

N2 - Perdeuterated poly(N-isopropylacrylamide) (PNIPAM-d10) is synthesized by free radical polymerization and characterized by 2H NMR, Fourier-transform infrared, and Raman spectroscopy. A concentrated solution of this polymer in H2O is investigated with respect to the dynamics of the hydration and bulk water using quasi-elastic neutron scattering. Due to the exchange of the protons in the polymer with deuterons, the incoherent neutron scattering from the polymer is suppressed, offsetting apart the hydration water. Deuteration causes a remarkable upward shift of the cloud point temperature by 4 °C. It is found that, when heating through the cloud point, the fraction of hydration water decreases abruptly. The relaxation time of the hydration water is consistently lower than the one observed previously for PNIPAM in H2O. Raman spectroscopy of the CD bands across the demixing transition shows a frequency shift consistent with polymer dehydration.

AB - Perdeuterated poly(N-isopropylacrylamide) (PNIPAM-d10) is synthesized by free radical polymerization and characterized by 2H NMR, Fourier-transform infrared, and Raman spectroscopy. A concentrated solution of this polymer in H2O is investigated with respect to the dynamics of the hydration and bulk water using quasi-elastic neutron scattering. Due to the exchange of the protons in the polymer with deuterons, the incoherent neutron scattering from the polymer is suppressed, offsetting apart the hydration water. Deuteration causes a remarkable upward shift of the cloud point temperature by 4 °C. It is found that, when heating through the cloud point, the fraction of hydration water decreases abruptly. The relaxation time of the hydration water is consistently lower than the one observed previously for PNIPAM in H2O. Raman spectroscopy of the CD bands across the demixing transition shows a frequency shift consistent with polymer dehydration.

UR - https://www.scopus.com/pages/publications/105035740124

U2 - 10.1021/acs.macromol.5c03241

DO - 10.1021/acs.macromol.5c03241

M3 - Article

AN - SCOPUS:105035740124

SN - 0024-9297

VL - 59

SP - 4124

EP - 4133

JO - Macromolecules

JF - Macromolecules

IS - 7

ER -

Hydration Dynamics of Perdeuterated PNIPAM in Aqueous Solution

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