Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging

Ivan Olefir, Elena Mercep, Neal C. Burton, Saak V. Ovsepian, Vasilis Ntziachristos

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Expanding usage of small animal models in biomedical research necessitates development of technologies for structural, functional, or molecular imaging that can be readily integrated in the biological laboratory. Herein, we consider dual multispectral optoacoustic (OA) and ultrasound tomography based on curved ultrasound detector arrays and describe the performance achieved for hybrid morphological and physiological brain imaging of mice in vivo. We showcase coregistered hemodynamic parameters resolved by OA tomography under baseline conditions and during alterations of blood oxygen saturation. As an internal reference, we provide imaging of abdominal organs. We illustrate the performance advantages of hybrid curved detector ultrasound and OA tomography and discuss immediate and long-term implications of our findings in the context of animal and human studies.

Original languageEnglish
Article number086005
JournalJournal of Biomedical Optics
Volume21
Issue number8
DOIs
StatePublished - 1 Aug 2016

Keywords

  • Hybrid systems
  • brain tomography
  • in vivo imaging
  • multispectral optoacoustic tomography
  • oxygen saturation
  • photoacoustic

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