Human organomics: A fresh approach to understanding human development using single-cell transcriptomics

J. Gray Camp, Barbara Treutlein

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these ‘organoids’ into constituent parts, and reconstruct lineage trajectories during cell differentiation. In this Spotlight article we summarize the different approaches to performing single-cell transcriptomics on organoids, and discuss the opportunities and challenges of applying these techniques to generate organ-level, mechanistic models of human development and disease. Together, these technologies will move past characterization to the prediction of human developmental and disease-related phenomena.

Original languageEnglish
Pages (from-to)1584-1587
Number of pages4
JournalDevelopment (Cambridge)
Volume144
Issue number9
DOIs
StatePublished - 1 May 2017

Keywords

  • Human development
  • Organogenesis
  • Organoid
  • Pluripotent stem cell
  • Single-cell transcriptomics
  • Transcriptome

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