Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring

Viktor M. Eisenkolb, Lisa M. Held, Alexander Utzschmid, Xiao Xiong Lin, Sandro M. Krieg, Bernhard Meyer, Jens Gempt, Simon N. Jacob

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

There are vast gaps in our understanding of the organization and operation of the human nervous system at the level of individual neurons and their networks. Here, we report reliable and robust acute multichannel recordings using planar microelectrode arrays (MEAs) implanted intracortically in awake brain surgery with open craniotomies that grant access to large parts of the cortical hemisphere. We obtained high-quality extracellular neuronal activity at the microcircuit, local field potential level and at the cellular, single-unit level. Recording from the parietal association cortex, a region rarely explored in human single-unit studies, we demonstrate applications on these complementary spatial scales and describe traveling waves of oscillatory activity as well as single-neuron and neuronal population responses during numerical cognition, including operations with uniquely human number symbols. Intraoperative MEA recordings are practicable and can be scaled up to explore cellular and microcircuit mechanisms of a wide range of human brain functions.

Original languageEnglish
Article number112467
JournalCell Reports
Volume42
Issue number5
DOIs
StatePublished - 30 May 2023
Externally publishedYes

Keywords

  • CP: Neuroscience
  • awake neurosurgery
  • local field potentials
  • microelectrode array
  • neurotechnology
  • numerical cognition
  • single unit recording

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