Homogenous Iron-Catalysed Deuteration of Electron-Rich Arenes and Heteroarenes

Florian Bourriquen, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Deuterated organic molecules are of interest for many applications ranging from mechanistic investigations in basic organic and physical chemistry to the development of new pharmaceuticals. Thus, methodologies for isotope-labelling reactions continue to be important. Here, a convenient methodology for hydrogen/deuterium exchange reactions in electron-rich arenes is reported using simple iron salts and deuterium oxide as isotope source.

Original languageEnglish
Pages (from-to)332-336
Number of pages5
JournalSynlett
Volume34
Issue number4
DOIs
StatePublished - 1 Mar 2023
Externally publishedYes

Keywords

  • Lewis acid
  • catalysis
  • deuterium
  • heavy water
  • isotopic labelling

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