Homogeneous cobalt-catalyzed deoxygenative hydrogenation of amides to amines

Veronica Papa, Jose R. Cabrero-Antonino, Anke Spannenberg, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The first general and efficient cobalt-catalyzed deoxygenative hydrogenation of amides to amines is presented. The optimal catalytic system based on a combination of [Co(NTf2)2] and (p-anisyl)triphos (L3) in the presence of [Me3SiOTf] as acidic co-catalyst facilitates the direct hydrogenation of a broad range of amides to the corresponding amines under mild conditions. A set of control experiments indicate that, after the initial reduction of the amide carboxylic group to the well-known hemiaminal intermediate, the reaction mainly proceeds through C-O bond cleavage though other pathways might be also involved to a minor extent.

Original languageEnglish
Pages (from-to)6116-6128
Number of pages13
JournalCatalysis Science and Technology
Volume10
Issue number18
DOIs
StatePublished - 21 Sep 2020
Externally publishedYes

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