HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation

Ute Feger, Eva Tolosa, Yu Hwa Huang, Anne Waschbisch, Tilo Biedermann, Arthur Melms, Heinz Wiendl

Research output: Contribution to journalArticlepeer-review

161 Scopus citations

Abstract

Regulatory T cells can inhibit harmful immunopathologic responses directed against self and foreign antigens and play a major role in controlling autoimmunity. Here we have identified and characterized a subpopulation of CD4 and CD8 T cells in human peripheral blood expressing the immune tolerizing molecule HLA-G. HLAG-expressing T cells are hypoproliferative, are CD25- and FOXP3-negative, and exhibit potent suppressive properties that are partially mediated by HLA-G. HLA-G-positive (HLA-Gpos) T cells are found at low percentages among CD4 and CD8 single-positive thymocytes, suggesting a thymic origin. The presence of HLA-Gpos T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo.

Original languageEnglish
Pages (from-to)568-577
Number of pages10
JournalBlood
Volume110
Issue number2
DOIs
StatePublished - 15 Jul 2007
Externally publishedYes

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