History of thyroid disease and survival of ovarian cancer patients: Results from the Ovarian Cancer Association Consortium, a brief report

Albina N. Minlikeeva, Jo L. Freudenheim, Rikki A. Cannioto, Kevin H. Eng, J. Brian Szender, Paul Mayor, John L. Etter, Daniel W. Cramer, Brenda Diergaarde, Jennifer A. Doherty, Thilo Dörk, Robert Edwards, Anna Defazio, Grace Friel, Marc T. Goodman, Peter Hillemanns, Estrid Høgdall, Allan Jensen, Susan J. Jordan, Beth Y. KarlanSusanne K. Kjær, Rüdiger Klapdor, Keitaro Matsuo, Mika Mizuno, Christina M. Nagle, Kunle Odunsi, Lisa Paddock, Mary Anne Rossing, Joellen M. Schildkraut, Barbara Schmalfeldt, Brahm H. Segal, Kristen Starbuck, Kathryn L. Terry, Penelope M. Webb, Emese Zsiros, Roberta B. Ness, Francesmary Modugno, Elisa V. Bandera, Jenny Chang-Claude, Kirsten B. Moysich

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background:Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited.Methods:We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper-and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer.Results:Overall, there was a nonsignificant association with history of hyperthyroidism (n=160 cases) and mortality (HR=1.22; 95% CI=0.97-1.53). Furthermore, diagnosis of hyperthyroidism within the 5 years before ovarian cancer diagnosis was associated with an increased risk of death (HR=1.94; 95% CI=1.19-3.18). A more modest association was observed with history of hypothyroidism (n=624 cases) and mortality (HR=1.16; 95% CI=1.03-1.31). Neither duration of hypothyroidism nor use of thyroid medications was associated with survival.Conclusions:In this large study of women with ovarian cancer, we found that recent history of hyperthyroidism and overall history of hypothyroidism were associated with worse 5-year survival.

Original languageEnglish
Pages (from-to)1063-1069
Number of pages7
JournalBritish Journal of Cancer
Issue number7
StatePublished - 26 Sep 2017
Externally publishedYes


  • hyperthyroidism
  • hypothyroidism
  • ovarian cancer
  • prognosis
  • survival


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