Histone Modifications in Stem Cell Development and Their Clinical Implications

Moritz Völker-Albert; Abel Bronkhorst; Stefan Holdenrieder; Axel Imhof

doi:10.1016/j.stemcr.2020.11.002

Histone Modifications in Stem Cell Development and Their Clinical Implications

Moritz Völker-Albert, Abel Bronkhorst, Stefan Holdenrieder, Axel Imhof

Institute of Laboratory Medicine

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

In this article, Axel Imhof and colleagues discuss recent findings on the role of histone modifications in stem cell regulation. In particular, this article focuses on the effects of global processes such as the cell cycle or the metabolic state on chromatin maturation and links them to targeted therapeutic interventions aiming to reset the epigenetic landscape.

Original language	English
Pages (from-to)	1196-1205
Number of pages	10
Journal	Stem Cell Reports
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.stemcr.2020.11.002
State	Published - 8 Dec 2020

Keywords

cell cycle
chromatin
epigenetics
histone modifications
metabolism
stem cells

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10.1016/j.stemcr.2020.11.002

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title = "Histone Modifications in Stem Cell Development and Their Clinical Implications",

abstract = "In this article, Axel Imhof and colleagues discuss recent findings on the role of histone modifications in stem cell regulation. In particular, this article focuses on the effects of global processes such as the cell cycle or the metabolic state on chromatin maturation and links them to targeted therapeutic interventions aiming to reset the epigenetic landscape.",

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AU - Bronkhorst, Abel

AU - Holdenrieder, Stefan

AU - Imhof, Axel

PY - 2020/12/8

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AB - In this article, Axel Imhof and colleagues discuss recent findings on the role of histone modifications in stem cell regulation. In particular, this article focuses on the effects of global processes such as the cell cycle or the metabolic state on chromatin maturation and links them to targeted therapeutic interventions aiming to reset the epigenetic landscape.

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KW - chromatin

KW - epigenetics

KW - histone modifications

KW - metabolism

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Histone Modifications in Stem Cell Development and Their Clinical Implications

Abstract

Keywords

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