Highly enantioselective Ru-catalyzed asymmetric hydrogenation of β-keto ester in ionic liquid/methanol mixtures

Eva Öchsner, Karola Schneiders, Kathrin Junge, Matthias Beller, Peter Wasserscheid

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The enantioselective hydrogenation of methyl acetoacetate (MAA) was studied in detail using a ruthenium-monodentate binaphthophosphepine complex in a homogeneous solution formed by different ionic liquids and methanol. Remarkably, ionic liquid additives did not only open an attractive way for catalyst recycling in repetitive batch-mode but also led to significantly increased catalytic activity compared to pure methanol. Enantioselectivities up to 95% have been achieved in mixed ionic liquid/methanol systems which are comparable to the values obtained in pure methanol.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalApplied Catalysis A: General
Volume364
Issue number1-2
DOIs
StatePublished - 31 Jul 2009
Externally publishedYes

Keywords

  • Asymmetric catalysis
  • Hydrogenation
  • Ionic liquid
  • Keto ester
  • Ketones

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