TY - GEN
T1 - High resolution imaging of mouse anatomy and molecular probes in mice by means of multispectral optoacoustic tomography (MSOT)
AU - Buehler, Andreas
AU - Morscher, Stefan
AU - Razansky, Daniel
AU - Ntziachristos, Vasilis
PY - 2012
Y1 - 2012
N2 - The ability to detect molecular probes in deep tissue, based on optical signatures, has been limited by tissue scattering, which reduces the spatial resolution and complicates quantification. To address this challenge, multispectral optoacoustic tomography (MSOT) has been recently introduced, a hybrid technology that capitalizes on the optoacoustic effect to combine rich optical contrast with the high spatial resolution and real-time operation of ultrasound. Using multiwavelength illumination MSOT can visualize molecular probes based on their distinct optical absorption spectra through several millimeters to centimeters of tissue. Herein we present a whole body multi-spectral optoacoustic tomography system and report on spectral processing techniques for detection of molecular probes in living mice.
AB - The ability to detect molecular probes in deep tissue, based on optical signatures, has been limited by tissue scattering, which reduces the spatial resolution and complicates quantification. To address this challenge, multispectral optoacoustic tomography (MSOT) has been recently introduced, a hybrid technology that capitalizes on the optoacoustic effect to combine rich optical contrast with the high spatial resolution and real-time operation of ultrasound. Using multiwavelength illumination MSOT can visualize molecular probes based on their distinct optical absorption spectra through several millimeters to centimeters of tissue. Herein we present a whole body multi-spectral optoacoustic tomography system and report on spectral processing techniques for detection of molecular probes in living mice.
KW - Molecular probe detection
KW - Multispectral optoacoustic tomography
KW - Photoacoustic imaging
UR - http://www.scopus.com/inward/record.url?scp=84859305872&partnerID=8YFLogxK
U2 - 10.1117/12.908230
DO - 10.1117/12.908230
M3 - Conference contribution
AN - SCOPUS:84859305872
SN - 9780819488664
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
T2 - Photons Plus Ultrasound: Imaging and Sensing 2012
Y2 - 22 January 2012 through 24 January 2012
ER -