High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolates

S. Viazov; F. Ratjen; R. Scheidhauer; M. Fiedler; M. Roggendorf

doi:10.1128/JCM.41.7.3043-3045.2003

High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolates

S. Viazov, F. Ratjen, R. Scheidhauer, M. Fiedler, M. Roggendorf

University Hospital of Essen

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

RNA of the newly identified human metapneumovirus (HMPV) was detected in nasopharyngeal aspirates of 11 of 63 (17.5%) young children with respiratory tract disease. Markers of infection caused by another member of the Pneumovirinae subfamily of the family Paramyxoviridae, respiratory syncytial virus (RSV), were identified in 15 of these patients (23.8%). Three patients were simultaneously infected with HMPV and RSV. Studies of the clinical characteristics of HMPV-infected children did not reveal any difference between HMPV-infected patients and a control population of RSV-infected patients with regard to disease severity, but the duration of symptoms was significantly shorter for HMPV-infected patients. Phylogenetic analysis of the amplified viral genome fragments confirmed the existence and simultaneous circulation within one epidemic season of HMPV isolates belonging to two genetic lineages.

Original language	English
Pages (from-to)	3043-3045
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	41
Issue number	7
DOIs	https://doi.org/10.1128/JCM.41.7.3043-3045.2003
State	Published - 1 Jul 2003
Externally published	Yes

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10.1128/JCM.41.7.3043-3045.2003

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abstract = "RNA of the newly identified human metapneumovirus (HMPV) was detected in nasopharyngeal aspirates of 11 of 63 (17.5%) young children with respiratory tract disease. Markers of infection caused by another member of the Pneumovirinae subfamily of the family Paramyxoviridae, respiratory syncytial virus (RSV), were identified in 15 of these patients (23.8%). Three patients were simultaneously infected with HMPV and RSV. Studies of the clinical characteristics of HMPV-infected children did not reveal any difference between HMPV-infected patients and a control population of RSV-infected patients with regard to disease severity, but the duration of symptoms was significantly shorter for HMPV-infected patients. Phylogenetic analysis of the amplified viral genome fragments confirmed the existence and simultaneous circulation within one epidemic season of HMPV isolates belonging to two genetic lineages.",

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AU - Fiedler, M.

AU - Roggendorf, M.

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High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolates

Abstract

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