HIAPP forms toxic oligomers in plasma

Diana C. Rodriguez Camargo; Divita Garg; Katalin Buday; Andras Franko; Andres Rodriguez Camargo; Fabian Schmidt; Sarah J. Cox; Saba Suladze; Martin Haslbeck; Yonatan G. Mideksa; Gerd Gemmecker; Michaela Aichler; Gabriele Mettenleiter; Michael Schulz; Axel Karl Walch; Martin Hrabě De Angelis; Matthias J. Feige; Cesar A. Sierra; Marcus Conrad; Konstantinos Tripsianes; Ayyalusamy Ramamoorthy; Bernd Reif

doi:10.1039/c8cc03097a

HIAPP forms toxic oligomers in plasma

Diana C. Rodriguez Camargo, Divita Garg, Katalin Buday, Andras Franko, Andres Rodriguez Camargo, Fabian Schmidt, Sarah J. Cox, Saba Suladze, Martin Haslbeck, Yonatan G. Mideksa, Gerd Gemmecker, Michaela Aichler, Gabriele Mettenleiter, Michael Schulz, Axel Karl Walch, Martin Hrabě De Angelis, Matthias J. Feige, Cesar A. Sierra, Marcus Conrad, Konstantinos TripsianesAyyalusamy Ramamoorthy, Bernd Reif

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31 Scopus citations

Abstract

In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

Original language	English
Pages (from-to)	5426-5429
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	43
DOIs	https://doi.org/10.1039/c8cc03097a
State	Published - 2018

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Rodriguez Camargo, D. C., Garg, D., Buday, K., Franko, A., Rodriguez Camargo, A., Schmidt, F., Cox, S. J., Suladze, S., Haslbeck, M., Mideksa, Y. G., Gemmecker, G., Aichler, M., Mettenleiter, G., Schulz, M., Walch, A. K., Hrabě De Angelis, M., Feige, M. J., Sierra, C. A., Conrad, M., ... Reif, B. (2018). HIAPP forms toxic oligomers in plasma. Chemical Communications, 54(43), 5426-5429. https://doi.org/10.1039/c8cc03097a

@article{d5782e854cd246f79e47e2415f12b224,

title = "HIAPP forms toxic oligomers in plasma",

abstract = "In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.",

author = "{Rodriguez Camargo}, {Diana C.} and Divita Garg and Katalin Buday and Andras Franko and {Rodriguez Camargo}, Andres and Fabian Schmidt and Cox, {Sarah J.} and Saba Suladze and Martin Haslbeck and Mideksa, {Yonatan G.} and Gerd Gemmecker and Michaela Aichler and Gabriele Mettenleiter and Michael Schulz and Walch, {Axel Karl} and {Hrab{\v e} De Angelis}, Martin and Feige, {Matthias J.} and Sierra, {Cesar A.} and Marcus Conrad and Konstantinos Tripsianes and Ayyalusamy Ramamoorthy and Bernd Reif",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2018.",

year = "2018",

doi = "10.1039/c8cc03097a",

language = "English",

volume = "54",

pages = "5426--5429",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "43",

}

Rodriguez Camargo, DC, Garg, D, Buday, K, Franko, A, Rodriguez Camargo, A, Schmidt, F, Cox, SJ, Suladze, S, Haslbeck, M, Mideksa, YG, Gemmecker, G, Aichler, M, Mettenleiter, G, Schulz, M, Walch, AK, Hrabě De Angelis, M, Feige, MJ, Sierra, CA, Conrad, M, Tripsianes, K, Ramamoorthy, A & Reif, B 2018, 'HIAPP forms toxic oligomers in plasma', Chemical Communications, vol. 54, no. 43, pp. 5426-5429. https://doi.org/10.1039/c8cc03097a

TY - JOUR

T1 - HIAPP forms toxic oligomers in plasma

AU - Rodriguez Camargo, Diana C.

AU - Garg, Divita

AU - Buday, Katalin

AU - Franko, Andras

AU - Rodriguez Camargo, Andres

AU - Schmidt, Fabian

AU - Cox, Sarah J.

AU - Suladze, Saba

AU - Haslbeck, Martin

AU - Mideksa, Yonatan G.

AU - Gemmecker, Gerd

AU - Aichler, Michaela

AU - Mettenleiter, Gabriele

AU - Schulz, Michael

AU - Walch, Axel Karl

AU - Hrabě De Angelis, Martin

AU - Feige, Matthias J.

AU - Sierra, Cesar A.

AU - Conrad, Marcus

AU - Tripsianes, Konstantinos

AU - Ramamoorthy, Ayyalusamy

AU - Reif, Bernd

PY - 2018

Y1 - 2018

N2 - In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

AB - In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

UR - http://www.scopus.com/inward/record.url?scp=85047566079&partnerID=8YFLogxK

U2 - 10.1039/c8cc03097a

DO - 10.1039/c8cc03097a

M3 - Article

C2 - 29745410

AN - SCOPUS:85047566079

SN - 1359-7345

VL - 54

SP - 5426

EP - 5429

JO - Chemical Communications

JF - Chemical Communications

IS - 43

ER -

HIAPP forms toxic oligomers in plasma

Abstract

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