Heterosynaptic Plasticity Determines the Set Point for Cortical Excitatory-Inhibitory Balance

Rachel E. Field; James A. D'amour; Robin Tremblay; Christoph Miehl; Bernardo Rudy; Julijana Gjorgjieva; Robert C. Froemke

doi:10.1016/j.neuron.2020.03.002

Heterosynaptic Plasticity Determines the Set Point for Cortical Excitatory-Inhibitory Balance

Rachel E. Field, James A. D'amour, Robin Tremblay, Christoph Miehl, Bernardo Rudy, Julijana Gjorgjieva, Robert C. Froemke

Associate Professorship of Computational Neuroscience

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

After induction of synaptic plasticity at specific inputs, Field et al. found that coordinated changes occur across multiple inhibitory and excitatory inputs onto cortical pyramidal neurons. The relative timing and degree of heterosynaptic plasticity determines the overall excitatory-inhibitory correlation, i.e., the set point for excitatory-inhibitory balance.

Original language	English
Pages (from-to)	842-854.e4
Journal	Neuron
Volume	106
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2020.03.002
State	Published - 3 Jun 2020

Keywords

Ca signaling
LTP
STDP
cortex
excitatory-inhibitory balance
inhibition
modeling
plasticity

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10.1016/j.neuron.2020.03.002

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abstract = "After induction of synaptic plasticity at specific inputs, Field et al. found that coordinated changes occur across multiple inhibitory and excitatory inputs onto cortical pyramidal neurons. The relative timing and degree of heterosynaptic plasticity determines the overall excitatory-inhibitory correlation, i.e., the set point for excitatory-inhibitory balance.",

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author = "Field, {Rachel E.} and D'amour, {James A.} and Robin Tremblay and Christoph Miehl and Bernardo Rudy and Julijana Gjorgjieva and Froemke, {Robert C.}",

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AU - Rudy, Bernardo

AU - Gjorgjieva, Julijana

AU - Froemke, Robert C.

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KW - LTP

KW - STDP

KW - cortex

KW - excitatory-inhibitory balance

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KW - modeling

KW - plasticity

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Heterosynaptic Plasticity Determines the Set Point for Cortical Excitatory-Inhibitory Balance

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Keywords

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