Heterosynaptic Plasticity Determines the Set Point for Cortical Excitatory-Inhibitory Balance

Rachel E. Field, James A. D'amour, Robin Tremblay, Christoph Miehl, Bernardo Rudy, Julijana Gjorgjieva, Robert C. Froemke

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

After induction of synaptic plasticity at specific inputs, Field et al. found that coordinated changes occur across multiple inhibitory and excitatory inputs onto cortical pyramidal neurons. The relative timing and degree of heterosynaptic plasticity determines the overall excitatory-inhibitory correlation, i.e., the set point for excitatory-inhibitory balance.

Original languageEnglish
Pages (from-to)842-854.e4
JournalNeuron
Volume106
Issue number5
DOIs
StatePublished - 3 Jun 2020

Keywords

  • Ca signaling
  • LTP
  • STDP
  • cortex
  • excitatory-inhibitory balance
  • inhibition
  • modeling
  • plasticity

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