Herpes zoster by reactivated vaccine varicella zoster virus in a healthy child

Barbara Uebe, Andreas Sauerbrei, Stefan Burdach, Gerd Horneff

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Varicella can be prevented by vaccination using the live-attenuated Oka vaccine strain of varicella zoster virus (VZV). Only mild breakthrough disease has been reported in seronegative vaccinees when exposed to the wild-type virus. The latent varicella vaccine virus has rarely caused herpes zoster in childhood and adolescence. We report a healthy 2-year-old girl who developed an impressive herpes zoster infection 16 months after vaccination, localised in three cervical dermatoma. As causative virus, VZV vaccine strain was identified by polymerase chain reaction and analysis of restriction fragment length polymorphisms of the amplified products. Conclusion: vaccine varicella zoster virus can occasionally reactivate in healthy children and present as herpes zoster. Virus characterisation is necessary to identify the strain and provide information on the incidence of occurrence.

Original languageEnglish
Pages (from-to)442-444
Number of pages3
JournalEuropean Journal of Pediatrics
Issue number8
StatePublished - 2002
Externally publishedYes


  • Herpes zoster
  • Varicella vaccination
  • Varicella zoster virus strain Oka
  • Viral differentiation
  • Wild-type varicella zoster virus


Dive into the research topics of 'Herpes zoster by reactivated vaccine varicella zoster virus in a healthy child'. Together they form a unique fingerprint.

Cite this