Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction

Janine Zöllkau; Juliane Ankert; Mathias W. Pletz; Sasmita Mishra; Gregor Seliger; Silvia M. Lobmaier; Clarissa U. Prazeres Da Costa; Vera Seidel; Katharina von Weizsäcker; Alexandra Jablonka; Christian Dopfer; Michael Baier; Thomas Horvatits; Ingrid Reiter-Owona; Tanja Groten; Benjamin T. Schleenvoigt

doi:10.3390/pathogens11010058

Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction

Janine Zöllkau, Juliane Ankert, Mathias W. Pletz, Sasmita Mishra, Gregor Seliger, Silvia M. Lobmaier, Clarissa U. Prazeres Da Costa, Vera Seidel, Katharina von Weizsäcker, Alexandra Jablonka, Christian Dopfer, Michael Baier, Thomas Horvatits, Ingrid Reiter-Owona, Tanja Groten, Benjamin T. Schleenvoigt

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Infections, as well as adverse birth outcomes, may be more frequent in migrant women. Schistosomiasis, echinococcosis, and hepatitis E virus (HEV) seropositivity are associated with the adverse pregnancy outcomes of fetal growth restriction and premature delivery. Methods: A cohort study of 82 pregnant women with a history of migration and corresponding delivery of newborns in Germany was conducted. Results: Overall, 9% of sera tested positive for anti-HEV IgG. None of the patients tested positive for anti-HEV IgM, schistosomiasis, or echinococcus serology. Birth weights were below the 10th percentile for gestational age in 8.5% of the neonates. No association between HEV serology and fetal growth restriction (FGR) frequency was found. Conclusions: In comparison to German baseline data, no increased risk for HEV exposure or serological signs of exposure against schistosomiasis or echinococcosis could be observed in pregnant migrants. An influence of the anti-HEV serology status on fetal growth restriction could not be found.

Original language	English
Article number	58
Journal	Pathogens
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/pathogens11010058
State	Published - Jan 2022
Externally published	Yes

Keywords

Echinococcosis
Fetal growth restriction
Hepatitis E
Migrants
Pregnancy
Schistosomiasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pathogens11010058

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Zöllkau, J., Ankert, J., Pletz, M. W., Mishra, S., Seliger, G., Lobmaier, S. M., Prazeres Da Costa, C. U., Seidel, V., von Weizsäcker, K., Jablonka, A., Dopfer, C., Baier, M., Horvatits, T., Reiter-Owona, I., Groten, T., & Schleenvoigt, B. T. (2022). Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction. Pathogens, 11(1), Article 58. https://doi.org/10.3390/pathogens11010058

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title = "Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction",

abstract = "Background: Infections, as well as adverse birth outcomes, may be more frequent in migrant women. Schistosomiasis, echinococcosis, and hepatitis E virus (HEV) seropositivity are associated with the adverse pregnancy outcomes of fetal growth restriction and premature delivery. Methods: A cohort study of 82 pregnant women with a history of migration and corresponding delivery of newborns in Germany was conducted. Results: Overall, 9% of sera tested positive for anti-HEV IgG. None of the patients tested positive for anti-HEV IgM, schistosomiasis, or echinococcus serology. Birth weights were below the 10th percentile for gestational age in 8.5% of the neonates. No association between HEV serology and fetal growth restriction (FGR) frequency was found. Conclusions: In comparison to German baseline data, no increased risk for HEV exposure or serological signs of exposure against schistosomiasis or echinococcosis could be observed in pregnant migrants. An influence of the anti-HEV serology status on fetal growth restriction could not be found.",

keywords = "Echinococcosis, Fetal growth restriction, Hepatitis E, Migrants, Pregnancy, Schistosomiasis",

author = "Janine Z{\"o}llkau and Juliane Ankert and Pletz, {Mathias W.} and Sasmita Mishra and Gregor Seliger and Lobmaier, {Silvia M.} and {Prazeres Da Costa}, {Clarissa U.} and Vera Seidel and {von Weizs{\"a}cker}, Katharina and Alexandra Jablonka and Christian Dopfer and Michael Baier and Thomas Horvatits and Ingrid Reiter-Owona and Tanja Groten and Schleenvoigt, {Benjamin T.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

doi = "10.3390/pathogens11010058",

language = "English",

volume = "11",

journal = "Pathogens",

issn = "2076-0817",

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Zöllkau, J, Ankert, J, Pletz, MW, Mishra, S, Seliger, G, Lobmaier, SM , Prazeres Da Costa, CU, Seidel, V, von Weizsäcker, K, Jablonka, A, Dopfer, C, Baier, M, Horvatits, T, Reiter-Owona, I, Groten, T & Schleenvoigt, BT 2022, 'Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction', Pathogens, vol. 11, no. 1, 58. https://doi.org/10.3390/pathogens11010058

TY - JOUR

T1 - Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction

AU - Zöllkau, Janine

AU - Ankert, Juliane

AU - Pletz, Mathias W.

AU - Mishra, Sasmita

AU - Seliger, Gregor

AU - Lobmaier, Silvia M.

AU - Prazeres Da Costa, Clarissa U.

AU - Seidel, Vera

AU - von Weizsäcker, Katharina

AU - Jablonka, Alexandra

AU - Dopfer, Christian

AU - Baier, Michael

AU - Horvatits, Thomas

AU - Reiter-Owona, Ingrid

AU - Groten, Tanja

AU - Schleenvoigt, Benjamin T.

PY - 2022/1

Y1 - 2022/1

N2 - Background: Infections, as well as adverse birth outcomes, may be more frequent in migrant women. Schistosomiasis, echinococcosis, and hepatitis E virus (HEV) seropositivity are associated with the adverse pregnancy outcomes of fetal growth restriction and premature delivery. Methods: A cohort study of 82 pregnant women with a history of migration and corresponding delivery of newborns in Germany was conducted. Results: Overall, 9% of sera tested positive for anti-HEV IgG. None of the patients tested positive for anti-HEV IgM, schistosomiasis, or echinococcus serology. Birth weights were below the 10th percentile for gestational age in 8.5% of the neonates. No association between HEV serology and fetal growth restriction (FGR) frequency was found. Conclusions: In comparison to German baseline data, no increased risk for HEV exposure or serological signs of exposure against schistosomiasis or echinococcosis could be observed in pregnant migrants. An influence of the anti-HEV serology status on fetal growth restriction could not be found.

AB - Background: Infections, as well as adverse birth outcomes, may be more frequent in migrant women. Schistosomiasis, echinococcosis, and hepatitis E virus (HEV) seropositivity are associated with the adverse pregnancy outcomes of fetal growth restriction and premature delivery. Methods: A cohort study of 82 pregnant women with a history of migration and corresponding delivery of newborns in Germany was conducted. Results: Overall, 9% of sera tested positive for anti-HEV IgG. None of the patients tested positive for anti-HEV IgM, schistosomiasis, or echinococcus serology. Birth weights were below the 10th percentile for gestational age in 8.5% of the neonates. No association between HEV serology and fetal growth restriction (FGR) frequency was found. Conclusions: In comparison to German baseline data, no increased risk for HEV exposure or serological signs of exposure against schistosomiasis or echinococcosis could be observed in pregnant migrants. An influence of the anti-HEV serology status on fetal growth restriction could not be found.

KW - Echinococcosis

KW - Fetal growth restriction

KW - Hepatitis E

KW - Migrants

KW - Pregnancy

KW - Schistosomiasis

UR - http://www.scopus.com/inward/record.url?scp=85122754887&partnerID=8YFLogxK

U2 - 10.3390/pathogens11010058

DO - 10.3390/pathogens11010058

M3 - Article

AN - SCOPUS:85122754887

SN - 2076-0817

VL - 11

JO - Pathogens

JF - Pathogens

IS - 1

M1 - 58

ER -

Hepatitis E, Schistosomiasis and Echinococcosis–Prevalence in a Cohort of Pregnant Migrants in Germany and Their Influence on Fetal Growth Restriction

Abstract

Keywords

UN SDGs

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